Abstract
Markers of types I and III collagen turnover were measured in serial blood samples in 16 patients with a Colles' fracture. The collagen markers were the carboxy-terminal extension peptide of type I procollagen (PICP) and the amino-terminal extension peptide of type III procollagen (PIIINP). Significant increases were found of PIIINP within 1 week and of PICP within 2 weeks. This sequential appearance of PIIINP and PICP was found to be in agreement with the appearance of types III and I collagen during early fracture healing as demonstrated in previous animal experimental studies. PICP had levelled off after 9 months, whereas PIIINP remained elevated. Osteocalcin, a serum marker of osteoblast activity, increased within 1 week and levelled off after 9 months. Correlations between the change in osteocalcin and those in PICP and PIIINP, respectively, were weak. These new biochemical markers may prove relevant as non-invasive markers of normal and pathological fracture healing in humans.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Archives of Orthopaedic and Trauma Surgery |
| Vol/bind | 111 |
| Udgave nummer | 5 |
| Sider (fra-til) | 265-7 |
| Antal sider | 3 |
| ISSN | 0936-8051 |
| Status | Udgivet - 1992 |