TY - JOUR
T1 - Type 2 diabetes mellitus
T2 - a metabolic autoinflammatory disease
AU - Mandrup-Poulsen, Thomas
N1 - Copyright © 2013 Elsevier Inc. All rights reserved.
PY - 2013/7
Y1 - 2013/7
N2 - The recent molecular, biologic, and genetic understanding of the inflammasome has revolutionized the diagnosis of and therapy for the phenotypically heterogeneous group of rare oligogenic disorders, now recognized to have autoinflammatory origin. This article reviews the importance of inflammasome activation in the central and peripheral mechanisms underlying a common, multifactorial, lifestyle-related, and polygenetic disease (type 2 diabetes mellitus), and conceptualizes the notion that this health challenge should now be recognized to have an autoinflammatory cause. It is hoped that targeting these mechanisms will enable the introduction of novel therapies that attack the basic pathogenetic mechanisms of type 2 diabetes mellitus rather than the epiphenomena that are its consequences.
AB - The recent molecular, biologic, and genetic understanding of the inflammasome has revolutionized the diagnosis of and therapy for the phenotypically heterogeneous group of rare oligogenic disorders, now recognized to have autoinflammatory origin. This article reviews the importance of inflammasome activation in the central and peripheral mechanisms underlying a common, multifactorial, lifestyle-related, and polygenetic disease (type 2 diabetes mellitus), and conceptualizes the notion that this health challenge should now be recognized to have an autoinflammatory cause. It is hoped that targeting these mechanisms will enable the introduction of novel therapies that attack the basic pathogenetic mechanisms of type 2 diabetes mellitus rather than the epiphenomena that are its consequences.
KW - Autoimmune Diseases
KW - Cytokines
KW - Diabetes Mellitus, Type 2
KW - Hereditary Autoinflammatory Diseases
KW - Humans
KW - Inflammasomes
U2 - 10.1016/j.det.2013.04.006
DO - 10.1016/j.det.2013.04.006
M3 - Journal article
C2 - 23827251
SN - 0733-8635
VL - 31
SP - 495
EP - 506
JO - Dermatologic Clinics
JF - Dermatologic Clinics
IS - 3
ER -
