@article{b239bab0ab6411ddb5e9000ea68e967b,
title = "Tubuloglomerular feedback in Dahl rats.",
abstract = "We have previously demonstrated a loss of autoregulation in Dahl salt-sensitive (Dahl-S) rats rendered hypertensive on a high-salt diet. To determine whether this was due to a decreased activity of either the myogenic or the tubuloglomerular feedback (TGF) response, we tested the TGF response in both Dahl-S and salt-resistant Dahl rats on high- and low-salt diets. TGF was investigated in the closed-loop mode with a videometric technique, in which the response in late proximal flow rate to perturbations in Henle flow rate was measured. All Dahl rats showed a similar compensatory response to perturbations around the natural operating point, with a TGF response that was more efficient than in normotensive Sprague-Dawley rats. No evidence of decreased TGF responsiveness in hypertensive Dahl-S rats was found. The results suggest that the loss of autoregulation in hypertensive Dahl-S rats is due to a compromised myogenic response. We also measured the free-flow proximal intratubular pressure in Dahl rats. Perfectly regular oscillations were demonstrated in all Dahl series, including the hypertensive Dahl-S rats. This is the first demonstration of regular oscillations in an experimental rat model of hypertension.",
author = "Karlsen, {F M} and Leyssac, {P P} and Holstein-Rathlou, {N H}",
note = "Keywords: Adaptation, Physiological; Animals; Blood Pressure; Diet, Sodium-Restricted; Drug Resistance; Feedback; Homeostasis; Hydrostatic Pressure; Hypertension; Kidney Glomerulus; Kidney Tubules, Proximal; Loop of Henle; Male; Rats; Rats, Inbred Dahl; Rats, Sprague-Dawley; Reference Values; Sodium Chloride",
year = "1998",
language = "English",
volume = "274",
pages = "R1561--9",
journal = "American Journal of Physiology (Consolidated)",
issn = "0002-9513",
publisher = "American Physiological Society",
number = "6 Pt 2",
}