TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

Per Jensen; Ling Feng; Ian Law; Claus Svarer; Gitte M Knudsen; Jens D Mikkelsen; Robin de Nijs; Vibeke A Larsen; Agnete Dyssegaard; Gerda Thomsen; Walter Fischer; Denis Guilloteau; Lars H Pinborg

doi:10.2967/jnumed.115.158998

TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between ¹²³I-CLINDE SPECT, ¹⁸F-FET PET, and Gadolinium-Enhanced MR Imaging

Per Jensen, Ling Feng, Ian Law, Claus Svarer, Gitte M Knudsen, Jens D Mikkelsen, Robin de Nijs, Vibeke A Larsen, Agnete Dyssegaard, Gerda Thomsen, Walter Fischer, Denis Guilloteau, Lars H Pinborg

Institut for Klinisk Medicin

23 Citationer (Scopus)

Abstract

Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4′-¹²³I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT (¹²³I-CLINDE) and amino acid transport imaging using O-(2-¹⁸F-fluoroethyl)-L-tyrosine PET (¹⁸F-FET) and investigate whether ¹²³I-CLINDE is superior to ¹⁸F-FET in predicting progression of glioblastoma multiforme (GBM) at follow-up. Methods: Three patients with World Health Organization grade IV GBM were scanned with ¹²³I-CLINDE SPECT, ¹⁸F-FET PET, and gadoliniumenhanced MR imaging. Molecular imaging data were compared with follow-up gadolinium-enhanced MR images or contrast-enhanced CT scans. Results: The percentage overlap between volumes of interest (VOIs) of increased ¹⁸F-FET uptake and ¹²³I-CLINDE binding was variable (12%-42%). The percentage overlap of MR imaging baseline VOIs was greater for ¹⁸F-FET (79%-93%) than ¹²³I-CLINDE (15%- 30%). In contrast, VOIs of increased contrast enhancement at followup compared with baseline overlapped to a greater extent with baseline ¹²³I-CLINDE VOIs than ¹⁸F-FET VOIs (21% vs. 8% and 72% vs. 55%). Conclusion: Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at followup and may be less susceptible to changes in blood-brain barrier permeability than ¹⁸F-FET. Larger studies are warranted to test the clinical potential of TSPO imaging in GBM, including presurgical planning and radiotherapy.

Originalsprog	Engelsk
Tidsskrift	Journal of Nuclear Medicine
Vol/bind	56
Udgave nummer	9
Sider (fra-til)	1386-90
Antal sider	5
ISSN	0161-5505
DOI	https://doi.org/10.2967/jnumed.115.158998
Status	Udgivet - 1 sep. 2015

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10.2967/jnumed.115.158998

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Citationsformater

Jensen, P., Feng, L., Law, I., Svarer, C., Knudsen, G. M., Mikkelsen, J. D., de Nijs, R., Larsen, V. A., Dyssegaard, A., Thomsen, G., Fischer, W., Guilloteau, D., & Pinborg, L. H. (2015). TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between ¹²³I-CLINDE SPECT, ¹⁸F-FET PET, and Gadolinium-Enhanced MR Imaging. Journal of Nuclear Medicine, 56(9), 1386-90. https://doi.org/10.2967/jnumed.115.158998

Jensen, P, Feng, L, Law, I, Svarer, C, Knudsen, GM, Mikkelsen, JD, de Nijs, R, Larsen, VA, Dyssegaard, A, Thomsen, G, Fischer, W, Guilloteau, D & Pinborg, LH 2015, 'TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between ¹²³I-CLINDE SPECT, ¹⁸F-FET PET, and Gadolinium-Enhanced MR Imaging', Journal of Nuclear Medicine, bind 56, nr. 9, s. 1386-90. https://doi.org/10.2967/jnumed.115.158998

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title = "TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging",

abstract = "Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4′-123I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT (123I-CLINDE) and amino acid transport imaging using O-(2-18F-fluoroethyl)-L-tyrosine PET (18F-FET) and investigate whether 123I-CLINDE is superior to 18F-FET in predicting progression of glioblastoma multiforme (GBM) at follow-up. Methods: Three patients with World Health Organization grade IV GBM were scanned with 123I-CLINDE SPECT, 18F-FET PET, and gadoliniumenhanced MR imaging. Molecular imaging data were compared with follow-up gadolinium-enhanced MR images or contrast-enhanced CT scans. Results: The percentage overlap between volumes of interest (VOIs) of increased 18F-FET uptake and 123I-CLINDE binding was variable (12%-42%). The percentage overlap of MR imaging baseline VOIs was greater for 18F-FET (79%-93%) than 123I-CLINDE (15%- 30%). In contrast, VOIs of increased contrast enhancement at followup compared with baseline overlapped to a greater extent with baseline 123I-CLINDE VOIs than 18F-FET VOIs (21% vs. 8% and 72% vs. 55%). Conclusion: Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at followup and may be less susceptible to changes in blood-brain barrier permeability than 18F-FET. Larger studies are warranted to test the clinical potential of TSPO imaging in GBM, including presurgical planning and radiotherapy.",

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author = "Per Jensen and Ling Feng and Ian Law and Claus Svarer and Knudsen, {Gitte M} and Mikkelsen, {Jens D} and {de Nijs}, Robin and Larsen, {Vibeke A} and Agnete Dyssegaard and Gerda Thomsen and Walter Fischer and Denis Guilloteau and Pinborg, {Lars H}",

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doi = "10.2967/jnumed.115.158998",

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T1 - TSPO Imaging in Glioblastoma Multiforme

T2 - A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

AU - Jensen, Per

AU - Feng, Ling

AU - Law, Ian

AU - Svarer, Claus

AU - Knudsen, Gitte M

AU - Mikkelsen, Jens D

AU - de Nijs, Robin

AU - Larsen, Vibeke A

AU - Dyssegaard, Agnete

AU - Thomsen, Gerda

AU - Fischer, Walter

AU - Guilloteau, Denis

AU - Pinborg, Lars H

PY - 2015/9/1

Y1 - 2015/9/1

N2 - Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4′-123I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT (123I-CLINDE) and amino acid transport imaging using O-(2-18F-fluoroethyl)-L-tyrosine PET (18F-FET) and investigate whether 123I-CLINDE is superior to 18F-FET in predicting progression of glioblastoma multiforme (GBM) at follow-up. Methods: Three patients with World Health Organization grade IV GBM were scanned with 123I-CLINDE SPECT, 18F-FET PET, and gadoliniumenhanced MR imaging. Molecular imaging data were compared with follow-up gadolinium-enhanced MR images or contrast-enhanced CT scans. Results: The percentage overlap between volumes of interest (VOIs) of increased 18F-FET uptake and 123I-CLINDE binding was variable (12%-42%). The percentage overlap of MR imaging baseline VOIs was greater for 18F-FET (79%-93%) than 123I-CLINDE (15%- 30%). In contrast, VOIs of increased contrast enhancement at followup compared with baseline overlapped to a greater extent with baseline 123I-CLINDE VOIs than 18F-FET VOIs (21% vs. 8% and 72% vs. 55%). Conclusion: Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at followup and may be less susceptible to changes in blood-brain barrier permeability than 18F-FET. Larger studies are warranted to test the clinical potential of TSPO imaging in GBM, including presurgical planning and radiotherapy.

AB - Here we compare translocator protein (TSPO) imaging using 6-chloro-2-(4′-123I-iodophenyl)-3-(N,N-diethyl)-imidazo[1,2-a]pyridine-3-acetamide SPECT (123I-CLINDE) and amino acid transport imaging using O-(2-18F-fluoroethyl)-L-tyrosine PET (18F-FET) and investigate whether 123I-CLINDE is superior to 18F-FET in predicting progression of glioblastoma multiforme (GBM) at follow-up. Methods: Three patients with World Health Organization grade IV GBM were scanned with 123I-CLINDE SPECT, 18F-FET PET, and gadoliniumenhanced MR imaging. Molecular imaging data were compared with follow-up gadolinium-enhanced MR images or contrast-enhanced CT scans. Results: The percentage overlap between volumes of interest (VOIs) of increased 18F-FET uptake and 123I-CLINDE binding was variable (12%-42%). The percentage overlap of MR imaging baseline VOIs was greater for 18F-FET (79%-93%) than 123I-CLINDE (15%- 30%). In contrast, VOIs of increased contrast enhancement at followup compared with baseline overlapped to a greater extent with baseline 123I-CLINDE VOIs than 18F-FET VOIs (21% vs. 8% and 72% vs. 55%). Conclusion: Our preliminary results suggest that TSPO brain imaging in GBM may be a useful tool for predicting tumor progression at followup and may be less susceptible to changes in blood-brain barrier permeability than 18F-FET. Larger studies are warranted to test the clinical potential of TSPO imaging in GBM, including presurgical planning and radiotherapy.

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KW - Bicyclo Compounds, Heterocyclic

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KW - Brain Neoplasms

KW - Female

KW - Fluorodeoxyglucose F18

KW - Gadolinium

KW - Glioblastoma

KW - Humans

KW - Image Interpretation, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Middle Aged

KW - Molecular Imaging

KW - Radiopharmaceuticals

KW - Receptors, GABA

KW - Reproducibility of Results

KW - Sensitivity and Specificity

KW - Tissue Distribution

KW - Tomography, Emission-Computed

KW - Tyrosine

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DO - 10.2967/jnumed.115.158998

M3 - Comment/debate

C2 - 26182972

SN - 0161-5505

VL - 56

SP - 1386

EP - 1390

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

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ER -

TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between 123I-CLINDE SPECT, 18F-FET PET, and Gadolinium-Enhanced MR Imaging

Abstract

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TSPO Imaging in Glioblastoma Multiforme: A Direct Comparison Between ¹²³I-CLINDE SPECT, ¹⁸F-FET PET, and Gadolinium-Enhanced MR Imaging