Troponin T is a strong marker of mortality in hospitalized patients

TY - JOUR

T1 - Troponin T is a strong marker of mortality in hospitalized patients

AU - Iversen, Kasper

AU - Køber, Lars

AU - Gøtze, Jens Peter

AU - Dalsgaard, Morten

AU - Nielsen, Henrik

AU - Boesgaard, Søren

AU - Bay, Morten

AU - Kirk, Vibeke

AU - Nielsen, Olav Wendelboe

N1 - Copyright © 2012 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/9/30

Y1 - 2013/9/30

N2 - BACKGROUND: Cardiac troponins are diagnostic markers in acute coronary syndrome and prognostic markers in stable coronary disease. Small increases are occasionally observed in patients with non-cardiac disease, but the prevalence and prognostic value of increased troponin in the general hospitalized population are unknown. METHODS: Consecutive patients aged >40years admitted to a district hospital between 1 April 1998 and 31 March 1999 were included. A comprehensive medical interview and clinical examination were performed including echocardiography and measurement of natriuretic peptides and troponin T with a high-sensitivity assay (hs-TnT). RESULTS: Serum for analyses of hs-TnT was available from 1176 patients. Patients were 73.7years old on average (interquartile range, 64.5-80.0years), 59.2% were women and median follow-up was 11.4years. The prevalence of elevated hs-TnT (> 99th percentile) was 57.1% of the entire cohort and 52.3% of patients with non-cardiac diagnoses. hs-TnT above the median (17ng/L) was associated in univariate analysis with a 3-fold higher mortality in the entire population (multivariate hazard rate (HR) from 1.3 to 1.8 for 1 and 11year mortality, respectively). In patients without past or present ischemic heart disease hs-TnT in the upper quartile (above 34.8ng/L) was associated in univariate analysis with a 5-fold higher mortality risk (multivariable HR 1.8 to 2.2 for 1 and 11year mortality, respectively). CONCLUSION: More than half of the hospitalized patients had hs-TnT levels above the 99th percentile. Elevated hs-TnT is a strong mortality risk marker in general hospitalized older patients.

AB - BACKGROUND: Cardiac troponins are diagnostic markers in acute coronary syndrome and prognostic markers in stable coronary disease. Small increases are occasionally observed in patients with non-cardiac disease, but the prevalence and prognostic value of increased troponin in the general hospitalized population are unknown. METHODS: Consecutive patients aged >40years admitted to a district hospital between 1 April 1998 and 31 March 1999 were included. A comprehensive medical interview and clinical examination were performed including echocardiography and measurement of natriuretic peptides and troponin T with a high-sensitivity assay (hs-TnT). RESULTS: Serum for analyses of hs-TnT was available from 1176 patients. Patients were 73.7years old on average (interquartile range, 64.5-80.0years), 59.2% were women and median follow-up was 11.4years. The prevalence of elevated hs-TnT (> 99th percentile) was 57.1% of the entire cohort and 52.3% of patients with non-cardiac diagnoses. hs-TnT above the median (17ng/L) was associated in univariate analysis with a 3-fold higher mortality in the entire population (multivariate hazard rate (HR) from 1.3 to 1.8 for 1 and 11year mortality, respectively). In patients without past or present ischemic heart disease hs-TnT in the upper quartile (above 34.8ng/L) was associated in univariate analysis with a 5-fold higher mortality risk (multivariable HR 1.8 to 2.2 for 1 and 11year mortality, respectively). CONCLUSION: More than half of the hospitalized patients had hs-TnT levels above the 99th percentile. Elevated hs-TnT is a strong mortality risk marker in general hospitalized older patients.

U2 - 10.1016/j.ijcard.2012.10.006

DO - 10.1016/j.ijcard.2012.10.006

M3 - Journal article

C2 - 23117016

SN - 0167-5273

JO - International Journal of Cardiology

JF - International Journal of Cardiology

ER -