Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave

Tanveer Ahmed Bhuiyan; Claus Graff; Morten Bækgaard Thomsen; Johannes J. Struijk

Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave

Tanveer Ahmed Bhuiyan, Claus Graff, Morten Bækgaard Thomsen, Johannes J. Struijk

Molecular Cardiology and Membrane Proteins

2 Citationer (Scopus)

Abstract

It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker sertindole and associated these changes to concurrent changes in the morphology of electrocardiographic T-waves in dogs. We show that, under the effect of sertindole, the peak changes in the morphology of action potentials occur at time points similar to those observed for the peak changes in T-wave morphology on the ECG. We further show that the association between action potential shape and ECG shape is dose-dependent and most prominent at the time corresponding to phase 3 of the action potential.

Originalsprog	Engelsk
Titel	Computing in Cardiology
Antal sider	4
Vol/bind	39
Publikationsdato	1 jan. 2012
Sider	757-760
ISBN (Trykt)	9781467320740
Status	Udgivet - 1 jan. 2012

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abstract = "It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker sertindole and associated these changes to concurrent changes in the morphology of electrocardiographic T-waves in dogs. We show that, under the effect of sertindole, the peak changes in the morphology of action potentials occur at time points similar to those observed for the peak changes in T-wave morphology on the ECG. We further show that the association between action potential shape and ECG shape is dose-dependent and most prominent at the time corresponding to phase 3 of the action potential.",

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AU - Bhuiyan, Tanveer Ahmed

AU - Graff, Claus

AU - Thomsen, Morten Bækgaard

AU - Struijk, Johannes J.

PY - 2012/1/1

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N2 - It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker sertindole and associated these changes to concurrent changes in the morphology of electrocardiographic T-waves in dogs. We show that, under the effect of sertindole, the peak changes in the morphology of action potentials occur at time points similar to those observed for the peak changes in T-wave morphology on the ECG. We further show that the association between action potential shape and ECG shape is dose-dependent and most prominent at the time corresponding to phase 3 of the action potential.

AB - It has been proposed that triangulation on the cardiac action potential manifests as a broadened, more flat and notched T-wave on the ECG but to what extent such morphology characteristics are indicative of triangulation is more unclear. In this paper, we have analyzed the morphological changes of the action potential under the effect of the IKr blocker sertindole and associated these changes to concurrent changes in the morphology of electrocardiographic T-waves in dogs. We show that, under the effect of sertindole, the peak changes in the morphology of action potentials occur at time points similar to those observed for the peak changes in T-wave morphology on the ECG. We further show that the association between action potential shape and ECG shape is dose-dependent and most prominent at the time corresponding to phase 3 of the action potential.

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Triangulation of the monophasic action potential causes flattening of the electrocardiographic T-wave

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