Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology

Anna-Karina A Henningsen; Christina Bergh; Rolv Skjaerven; Aila Tiitinen; Ulla-Britt Wennerholm; Liv B Romundstad; Mika Gissler; Signe Opdahl; Anders Nyboe Andersen; Øjvind Lidegaard; Julie L Forman; Anja Pinborg

doi:10.1111/aogs.13347

Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology

Anna-Karina A Henningsen, Christina Bergh, Rolv Skjaerven, Aila Tiitinen, Ulla-Britt Wennerholm, Liv B Romundstad, Mika Gissler, Signe Opdahl, Anders Nyboe Andersen, Øjvind Lidegaard, Julie L Forman, Anja Pinborg

9 Citationer (Scopus)

Abstract

INTRODUCTION: Children born after assisted reproductive technology, particularly singletons, have been shown to have an increased risk of congenital malformations compared with children born after spontaneous conception. We wished to study whether there has been a change in the past 20 years in the risk of major congenital malformations in children conceived after assisted reproductive technology compared with children spontaneously conceived.

MATERIAL AND METHODS: Population-based cohort study including 90 201 assisted reproductive technology children and 482 552 children spontaneously conceived, born in Denmark, Finland, Norway and Sweden. Both singletons and twins born after in vitro fertilization, intracytoplasmatic sperm injection and frozen embryo transfer were included. Data on children were taken from when the national Nordic assisted reproductive technology registries were established until 2007. Multiple logistic regression analyses were used to estimate the risks and adjusted odds ratios for congenital malformations in four time periods: 1988-1992, 1993-1997, 1998-2002 and 2003-2007. Only major malformations were included.

RESULTS: The absolute risk for singletons of being born with a major malformation was 3.4% among assisted reproductive technology children vs. 2.9% among children spontaneously conceived during the study period. The relative risk of being born with a major congenital malformation between all assisted reproductive technology children and children spontaneously conceived remained similar through all four time periods (p = 0.39). However, we found that over time the number of children diagnosed with a major malformation increased in both groups across all four time periods.

CONCLUSION: When comparing children conceived after assisted reproductive technology and spontaneously conceived, the relative risk of being born with a major congenital malformation did not change during the study period.

Originalsprog	Engelsk
Tidsskrift	Acta Obstetricia et Gynecologica Scandinavica
Vol/bind	97
Udgave nummer	7
Sider (fra-til)	816-823
Antal sider	8
ISSN	0001-6349
DOI	https://doi.org/10.1111/aogs.13347
Status	Udgivet - jul. 2018

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10.1111/aogs.13347

aogs.13347Forlagets udgivne version, 208 KB

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Henningsen, A-K. A., Bergh, C., Skjaerven, R., Tiitinen, A., Wennerholm, U-B., Romundstad, L. B., Gissler, M., Opdahl, S., Nyboe Andersen, A., Lidegaard, Ø., Forman, J. L., & Pinborg, A. (2018). Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology. Acta Obstetricia et Gynecologica Scandinavica, 97(7), 816-823. https://doi.org/10.1111/aogs.13347

Henningsen, A-KA, Bergh, C, Skjaerven, R, Tiitinen, A, Wennerholm, U-B, Romundstad, LB, Gissler, M, Opdahl, S, Nyboe Andersen, A, Lidegaard, Ø , Forman, JL & Pinborg, A 2018, 'Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology', Acta Obstetricia et Gynecologica Scandinavica, bind 97, nr. 7, s. 816-823. https://doi.org/10.1111/aogs.13347

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title = "Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology",

abstract = "INTRODUCTION: Children born after assisted reproductive technology, particularly singletons, have been shown to have an increased risk of congenital malformations compared with children born after spontaneous conception. We wished to study whether there has been a change in the past 20 years in the risk of major congenital malformations in children conceived after assisted reproductive technology compared with children spontaneously conceived.MATERIAL AND METHODS: Population-based cohort study including 90 201 assisted reproductive technology children and 482 552 children spontaneously conceived, born in Denmark, Finland, Norway and Sweden. Both singletons and twins born after in vitro fertilization, intracytoplasmatic sperm injection and frozen embryo transfer were included. Data on children were taken from when the national Nordic assisted reproductive technology registries were established until 2007. Multiple logistic regression analyses were used to estimate the risks and adjusted odds ratios for congenital malformations in four time periods: 1988-1992, 1993-1997, 1998-2002 and 2003-2007. Only major malformations were included.RESULTS: The absolute risk for singletons of being born with a major malformation was 3.4% among assisted reproductive technology children vs. 2.9% among children spontaneously conceived during the study period. The relative risk of being born with a major congenital malformation between all assisted reproductive technology children and children spontaneously conceived remained similar through all four time periods (p = 0.39). However, we found that over time the number of children diagnosed with a major malformation increased in both groups across all four time periods.CONCLUSION: When comparing children conceived after assisted reproductive technology and spontaneously conceived, the relative risk of being born with a major congenital malformation did not change during the study period.",

author = "Henningsen, {Anna-Karina A} and Christina Bergh and Rolv Skjaerven and Aila Tiitinen and Ulla-Britt Wennerholm and Romundstad, {Liv B} and Mika Gissler and Signe Opdahl and {Nyboe Andersen}, Anders and {\O}jvind Lidegaard and Forman, {Julie L} and Anja Pinborg",

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T1 - Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology

AU - Henningsen, Anna-Karina A

AU - Bergh, Christina

AU - Skjaerven, Rolv

AU - Tiitinen, Aila

AU - Wennerholm, Ulla-Britt

AU - Romundstad, Liv B

AU - Gissler, Mika

AU - Opdahl, Signe

AU - Nyboe Andersen, Anders

AU - Lidegaard, Øjvind

AU - Forman, Julie L

AU - Pinborg, Anja

PY - 2018/7

Y1 - 2018/7

N2 - INTRODUCTION: Children born after assisted reproductive technology, particularly singletons, have been shown to have an increased risk of congenital malformations compared with children born after spontaneous conception. We wished to study whether there has been a change in the past 20 years in the risk of major congenital malformations in children conceived after assisted reproductive technology compared with children spontaneously conceived.MATERIAL AND METHODS: Population-based cohort study including 90 201 assisted reproductive technology children and 482 552 children spontaneously conceived, born in Denmark, Finland, Norway and Sweden. Both singletons and twins born after in vitro fertilization, intracytoplasmatic sperm injection and frozen embryo transfer were included. Data on children were taken from when the national Nordic assisted reproductive technology registries were established until 2007. Multiple logistic regression analyses were used to estimate the risks and adjusted odds ratios for congenital malformations in four time periods: 1988-1992, 1993-1997, 1998-2002 and 2003-2007. Only major malformations were included.RESULTS: The absolute risk for singletons of being born with a major malformation was 3.4% among assisted reproductive technology children vs. 2.9% among children spontaneously conceived during the study period. The relative risk of being born with a major congenital malformation between all assisted reproductive technology children and children spontaneously conceived remained similar through all four time periods (p = 0.39). However, we found that over time the number of children diagnosed with a major malformation increased in both groups across all four time periods.CONCLUSION: When comparing children conceived after assisted reproductive technology and spontaneously conceived, the relative risk of being born with a major congenital malformation did not change during the study period.

AB - INTRODUCTION: Children born after assisted reproductive technology, particularly singletons, have been shown to have an increased risk of congenital malformations compared with children born after spontaneous conception. We wished to study whether there has been a change in the past 20 years in the risk of major congenital malformations in children conceived after assisted reproductive technology compared with children spontaneously conceived.MATERIAL AND METHODS: Population-based cohort study including 90 201 assisted reproductive technology children and 482 552 children spontaneously conceived, born in Denmark, Finland, Norway and Sweden. Both singletons and twins born after in vitro fertilization, intracytoplasmatic sperm injection and frozen embryo transfer were included. Data on children were taken from when the national Nordic assisted reproductive technology registries were established until 2007. Multiple logistic regression analyses were used to estimate the risks and adjusted odds ratios for congenital malformations in four time periods: 1988-1992, 1993-1997, 1998-2002 and 2003-2007. Only major malformations were included.RESULTS: The absolute risk for singletons of being born with a major malformation was 3.4% among assisted reproductive technology children vs. 2.9% among children spontaneously conceived during the study period. The relative risk of being born with a major congenital malformation between all assisted reproductive technology children and children spontaneously conceived remained similar through all four time periods (p = 0.39). However, we found that over time the number of children diagnosed with a major malformation increased in both groups across all four time periods.CONCLUSION: When comparing children conceived after assisted reproductive technology and spontaneously conceived, the relative risk of being born with a major congenital malformation did not change during the study period.

U2 - 10.1111/aogs.13347

DO - 10.1111/aogs.13347

M3 - Journal article

C2 - 29572867

SN - 0001-6349

VL - 97

SP - 816

EP - 823

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 7

ER -

Trends over time in congenital malformations in live-born children conceived after assisted reproductive technology

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