Treat-to-target in systemic lupus erythematosus: recommendations from an international task force

Ronald F van Vollenhoven; Marta Mosca; George Bertsias; David Isenberg; Annegret Kuhn; Kirsten Lerstrøm; Martin Aringer; Hendrika Bootsma; Dimitrios Boumpas; Ian N Bruce; Ricard Cervera; Ann Clarke; Nathalie Costedoat-Chalumeau; László Czirják; Ronald Derksen; Thomas Dörner; Caroline Gordon; Winfried Graninger; Frédéric Houssiau; Murat Inanc; Søren Jacobsen; David Jayne; Anna Jedryka-Goral; Adrian Levitsky; Roger Levy; Xavier Mariette; Eric Morand; Sandra Navarra; Irmgard Neumann; Anisur Rahman; Jozef Rovensky; Josef Smolen; Carlos Vasconcelos; Alexandre Voskuyl; Anne Voss; Helena Zakharova; Asad Zoma; Matthias Schneider

doi:10.1136/annrheumdis-2013-205139

Treat-to-target in systemic lupus erythematosus: recommendations from an international task force

Ronald F van Vollenhoven, Marta Mosca, George Bertsias, David Isenberg, Annegret Kuhn, Kirsten Lerstrøm, Martin Aringer, Hendrika Bootsma, Dimitrios Boumpas, Ian N Bruce, Ricard Cervera, Ann Clarke, Nathalie Costedoat-Chalumeau, László Czirják, Ronald Derksen, Thomas Dörner, Caroline Gordon, Winfried Graninger, Frédéric Houssiau, Murat InancSøren Jacobsen, David Jayne, Anna Jedryka-Goral, Adrian Levitsky, Roger Levy, Xavier Mariette, Eric Morand, Sandra Navarra, Irmgard Neumann, Anisur Rahman, Jozef Rovensky, Josef Smolen, Carlos Vasconcelos, Alexandre Voskuyl, Anne Voss, Helena Zakharova, Asad Zoma, Matthias Schneider

Institut for Klinisk Medicin

326 Citationer (Scopus)

Abstract

The principle of treating-to-target has been successfully applied to many diseases outside rheumatology and more recently to rheumatoid arthritis. Identifying appropriate therapeutic targets and pursuing these systematically has led to improved care for patients with these diseases and useful guidance for healthcare providers and administrators. Thus, an initiative to evaluate possible therapeutic targets and develop treat-to-target guidance was believed to be highly appropriate in the management of systemic lupus erythematosus (SLE) patients as well. Specialists in rheumatology, nephrology, dermatology, internal medicine and clinical immunology, and a patient representative, contributed to this initiative. The majority convened on three occasions in 2012-2013. Twelve topics of critical importance were identified and a systematic literature review was performed. The results were condensed and reformulated as recommendations, discussed, modified and voted upon. The finalised bullet points were analysed for degree of agreement among the task force. The Oxford Centre level of evidence (LoE, corresponding to the research questions) and grade of recommendation (GoR) were determined for each recommendation. The 12 systematic literature searches and their summaries led to 11 recommendations. Prominent features of these recommendations are targeting remission, preventing damage and improving quality of life. LoE and GoR of the recommendations were variable but agreement was >0.9 in each case. An extensive research agenda was identified, and four overarching principles were also agreed upon. Treat-to-target-in-SLE (T2T/SLE) recommendations were developed by a large task force of multispecialty experts and a patient representative. It is anticipated that 'treating-to-target' can and will be applicable to the care of patients with SLE.

Originalsprog	Engelsk
Tidsskrift	Annals of the Rheumatic Diseases
Vol/bind	73
Udgave nummer	6
Sider (fra-til)	958-967
Antal sider	10
ISSN	0003-4967
DOI	https://doi.org/10.1136/annrheumdis-2013-205139
Status	Udgivet - jun. 2014

Adgang til dokumentet

10.1136/annrheumdis-2013-205139

Citationsformater

van Vollenhoven, R. F., Mosca, M., Bertsias, G., Isenberg, D., Kuhn, A., Lerstrøm, K., Aringer, M., Bootsma, H., Boumpas, D., Bruce, I. N., Cervera, R., Clarke, A., Costedoat-Chalumeau, N., Czirják, L., Derksen, R., Dörner, T., Gordon, C., Graninger, W., Houssiau, F., ... Schneider, M. (2014). Treat-to-target in systemic lupus erythematosus: recommendations from an international task force. Annals of the Rheumatic Diseases, 73(6), 958-967. https://doi.org/10.1136/annrheumdis-2013-205139

van Vollenhoven, RF, Mosca, M, Bertsias, G, Isenberg, D, Kuhn, A, Lerstrøm, K, Aringer, M, Bootsma, H, Boumpas, D, Bruce, IN, Cervera, R, Clarke, A, Costedoat-Chalumeau, N, Czirják, L, Derksen, R, Dörner, T, Gordon, C, Graninger, W, Houssiau, F, Inanc, M, Jacobsen, S, Jayne, D, Jedryka-Goral, A, Levitsky, A, Levy, R, Mariette, X, Morand, E, Navarra, S, Neumann, I, Rahman, A, Rovensky, J, Smolen, J, Vasconcelos, C, Voskuyl, A, Voss, A, Zakharova, H, Zoma, A & Schneider, M 2014, 'Treat-to-target in systemic lupus erythematosus: recommendations from an international task force', Annals of the Rheumatic Diseases, bind 73, nr. 6, s. 958-967. https://doi.org/10.1136/annrheumdis-2013-205139

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title = "Treat-to-target in systemic lupus erythematosus: recommendations from an international task force",

abstract = "The principle of treating-to-target has been successfully applied to many diseases outside rheumatology and more recently to rheumatoid arthritis. Identifying appropriate therapeutic targets and pursuing these systematically has led to improved care for patients with these diseases and useful guidance for healthcare providers and administrators. Thus, an initiative to evaluate possible therapeutic targets and develop treat-to-target guidance was believed to be highly appropriate in the management of systemic lupus erythematosus (SLE) patients as well. Specialists in rheumatology, nephrology, dermatology, internal medicine and clinical immunology, and a patient representative, contributed to this initiative. The majority convened on three occasions in 2012-2013. Twelve topics of critical importance were identified and a systematic literature review was performed. The results were condensed and reformulated as recommendations, discussed, modified and voted upon. The finalised bullet points were analysed for degree of agreement among the task force. The Oxford Centre level of evidence (LoE, corresponding to the research questions) and grade of recommendation (GoR) were determined for each recommendation. The 12 systematic literature searches and their summaries led to 11 recommendations. Prominent features of these recommendations are targeting remission, preventing damage and improving quality of life. LoE and GoR of the recommendations were variable but agreement was >0.9 in each case. An extensive research agenda was identified, and four overarching principles were also agreed upon. Treat-to-target-in-SLE (T2T/SLE) recommendations were developed by a large task force of multispecialty experts and a patient representative. It is anticipated that 'treating-to-target' can and will be applicable to the care of patients with SLE.",

keywords = "Advisory Committees, Disease Management, Humans, Lupus Erythematosus, Systemic, Patient Care Planning, Remission Induction, Secondary Prevention",

author = "{van Vollenhoven}, {Ronald F} and Marta Mosca and George Bertsias and David Isenberg and Annegret Kuhn and Kirsten Lerstr{\o}m and Martin Aringer and Hendrika Bootsma and Dimitrios Boumpas and Bruce, {Ian N} and Ricard Cervera and Ann Clarke and Nathalie Costedoat-Chalumeau and L{\'a}szl{\'o} Czirj{\'a}k and Ronald Derksen and Thomas D{\"o}rner and Caroline Gordon and Winfried Graninger and Fr{\'e}d{\'e}ric Houssiau and Murat Inanc and S{\o}ren Jacobsen and David Jayne and Anna Jedryka-Goral and Adrian Levitsky and Roger Levy and Xavier Mariette and Eric Morand and Sandra Navarra and Irmgard Neumann and Anisur Rahman and Jozef Rovensky and Josef Smolen and Carlos Vasconcelos and Alexandre Voskuyl and Anne Voss and Helena Zakharova and Asad Zoma and Matthias Schneider",

year = "2014",

month = jun,

doi = "10.1136/annrheumdis-2013-205139",

language = "English",

volume = "73",

pages = "958--967",

journal = "Annals of the Rheumatic Diseases",

issn = "0003-4967",

publisher = "B M J Group",

number = "6",

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TY - JOUR

T1 - Treat-to-target in systemic lupus erythematosus

T2 - recommendations from an international task force

AU - van Vollenhoven, Ronald F

AU - Mosca, Marta

AU - Bertsias, George

AU - Isenberg, David

AU - Kuhn, Annegret

AU - Lerstrøm, Kirsten

AU - Aringer, Martin

AU - Bootsma, Hendrika

AU - Boumpas, Dimitrios

AU - Bruce, Ian N

AU - Cervera, Ricard

AU - Clarke, Ann

AU - Costedoat-Chalumeau, Nathalie

AU - Czirják, László

AU - Derksen, Ronald

AU - Dörner, Thomas

AU - Gordon, Caroline

AU - Graninger, Winfried

AU - Houssiau, Frédéric

AU - Inanc, Murat

AU - Jacobsen, Søren

AU - Jayne, David

AU - Jedryka-Goral, Anna

AU - Levitsky, Adrian

AU - Levy, Roger

AU - Mariette, Xavier

AU - Morand, Eric

AU - Navarra, Sandra

AU - Neumann, Irmgard

AU - Rahman, Anisur

AU - Rovensky, Jozef

AU - Smolen, Josef

AU - Vasconcelos, Carlos

AU - Voskuyl, Alexandre

AU - Voss, Anne

AU - Zakharova, Helena

AU - Zoma, Asad

AU - Schneider, Matthias

PY - 2014/6

Y1 - 2014/6

N2 - The principle of treating-to-target has been successfully applied to many diseases outside rheumatology and more recently to rheumatoid arthritis. Identifying appropriate therapeutic targets and pursuing these systematically has led to improved care for patients with these diseases and useful guidance for healthcare providers and administrators. Thus, an initiative to evaluate possible therapeutic targets and develop treat-to-target guidance was believed to be highly appropriate in the management of systemic lupus erythematosus (SLE) patients as well. Specialists in rheumatology, nephrology, dermatology, internal medicine and clinical immunology, and a patient representative, contributed to this initiative. The majority convened on three occasions in 2012-2013. Twelve topics of critical importance were identified and a systematic literature review was performed. The results were condensed and reformulated as recommendations, discussed, modified and voted upon. The finalised bullet points were analysed for degree of agreement among the task force. The Oxford Centre level of evidence (LoE, corresponding to the research questions) and grade of recommendation (GoR) were determined for each recommendation. The 12 systematic literature searches and their summaries led to 11 recommendations. Prominent features of these recommendations are targeting remission, preventing damage and improving quality of life. LoE and GoR of the recommendations were variable but agreement was >0.9 in each case. An extensive research agenda was identified, and four overarching principles were also agreed upon. Treat-to-target-in-SLE (T2T/SLE) recommendations were developed by a large task force of multispecialty experts and a patient representative. It is anticipated that 'treating-to-target' can and will be applicable to the care of patients with SLE.

AB - The principle of treating-to-target has been successfully applied to many diseases outside rheumatology and more recently to rheumatoid arthritis. Identifying appropriate therapeutic targets and pursuing these systematically has led to improved care for patients with these diseases and useful guidance for healthcare providers and administrators. Thus, an initiative to evaluate possible therapeutic targets and develop treat-to-target guidance was believed to be highly appropriate in the management of systemic lupus erythematosus (SLE) patients as well. Specialists in rheumatology, nephrology, dermatology, internal medicine and clinical immunology, and a patient representative, contributed to this initiative. The majority convened on three occasions in 2012-2013. Twelve topics of critical importance were identified and a systematic literature review was performed. The results were condensed and reformulated as recommendations, discussed, modified and voted upon. The finalised bullet points were analysed for degree of agreement among the task force. The Oxford Centre level of evidence (LoE, corresponding to the research questions) and grade of recommendation (GoR) were determined for each recommendation. The 12 systematic literature searches and their summaries led to 11 recommendations. Prominent features of these recommendations are targeting remission, preventing damage and improving quality of life. LoE and GoR of the recommendations were variable but agreement was >0.9 in each case. An extensive research agenda was identified, and four overarching principles were also agreed upon. Treat-to-target-in-SLE (T2T/SLE) recommendations were developed by a large task force of multispecialty experts and a patient representative. It is anticipated that 'treating-to-target' can and will be applicable to the care of patients with SLE.

KW - Advisory Committees

KW - Disease Management

KW - Humans

KW - Lupus Erythematosus, Systemic

KW - Patient Care Planning

KW - Remission Induction

KW - Secondary Prevention

U2 - 10.1136/annrheumdis-2013-205139

DO - 10.1136/annrheumdis-2013-205139

M3 - Journal article

C2 - 24739325

SN - 0003-4967

VL - 73

SP - 958

EP - 967

JO - Annals of the Rheumatic Diseases

JF - Annals of the Rheumatic Diseases

IS - 6

ER -

Treat-to-target in systemic lupus erythematosus: recommendations from an international task force

Abstract

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