Transmembrane signalling via HLA-DR molecules on T cells from a Sezary T-cell leukaemia line

TY - JOUR

T1 - Transmembrane signalling via HLA-DR molecules on T cells from a Sezary T-cell leukaemia line

AU - Geisler, C

AU - Kuhlmann, J

AU - Møller, T

AU - Plesner, T

AU - Rubin, B

N1 - Keywords: Antibodies, Monoclonal; Antigens, CD; Antigens, CD3; Antigens, Differentiation, T-Lymphocyte; Cells, Cultured; Cross-Linking Reagents; Gene Expression Regulation, Neoplastic; HLA-DR Antigens; Humans; Interleukin-2; Receptors, Antigen, T-Cell; Sezary Syndrome; Signal Transduction; T-Lymphocytes; Tumor Cells, Cultured

PY - 1990

Y1 - 1990

N2 - The human Sezary T-cell leukaemia line, HUT.78, represents a population of activated T cells, i.e. they are HLA-DR+ and IL-2R+. We have analysed the capacity of HUT.78 cells (1) to stimulate HLA-DR-specific T-cell lines or clones and (2) to be induced to synthesize IL-2 by anti-HLA-DR monoclonal antibodies. The results of our experiments show that HLA-DR molecules on HUT.78 cells can stimulate at least one HLA-DR-specific T-cell clone and can act as transmembrane signal transmitters.

AB - The human Sezary T-cell leukaemia line, HUT.78, represents a population of activated T cells, i.e. they are HLA-DR+ and IL-2R+. We have analysed the capacity of HUT.78 cells (1) to stimulate HLA-DR-specific T-cell lines or clones and (2) to be induced to synthesize IL-2 by anti-HLA-DR monoclonal antibodies. The results of our experiments show that HLA-DR molecules on HUT.78 cells can stimulate at least one HLA-DR-specific T-cell clone and can act as transmembrane signal transmitters.

M3 - Journal article

C2 - 2148646

SN - 0301-6323

VL - 32

SP - 731

EP - 735

JO - Scandinavian Journal of Immunology, Supplement

JF - Scandinavian Journal of Immunology, Supplement

IS - 6

ER -