Translation attenuation mechanism in unfolded protein response

TY - CHAP

T1 - Translation attenuation mechanism in unfolded protein response

AU - Trusina, Ala

AU - Papa, Feroz

AU - Tang, Chao

PY - 2008/12/1

Y1 - 2008/12/1

N2 - Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.

AB - Endoplasmic Reticulum is a cellular organelle where membrane and extracellular proteins are folded with the help of chaperons. Insulin is one example of such extracellular proteins. Unfolded Protein Response (UPR) is a cell response to an increased level of unfolded proteins in ER. In pancreatic β-cells failure in UPR leads to accumulation of unfolded insulin in Endoplasmic reticulum and eventual cell death. This is thought to be one of the causes of type two diabetes.

KW - Stress response

KW - Translational attenuation

KW - Unfolded protein response

KW - UPR

UR - http://www.scopus.com/inward/record.url?scp=77949445259&partnerID=8YFLogxK

U2 - 10.1007/978-1-4020-8761-5-6

DO - 10.1007/978-1-4020-8761-5-6

M3 - Book chapter

AN - SCOPUS:77949445259

SN - 9781402087608

T3 - NATO Science for Peace and Security Series B: Physics and Biophysics

SP - 83

EP - 90

BT - Evolution from Cellular to Social Scales

A2 - Skjeltorp, Arne

A2 - Skjeltorp, Arne

A2 - Belushkin, Alexander

ER -