TY - JOUR
T1 - Transfusion transmission of hepatitis A virus with fecal shedding in a previously hepatitis A vaccinated recipient
AU - Vestergaard, Hanne Thang
AU - Harritshøj, Lene Holm
AU - Midgley, Sofie Elisabeth
AU - Ullum, Henrik
AU - Kampmann, Peter
N1 - Copyright © 2018 Japanese Society of Chemotherapy and The Japanese Association for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
PY - 2018/9
Y1 - 2018/9
N2 - We describe a rare case of hepatitis A virus (HAV) replication in feces despite presence of hepatitis A antibodies in an acute myeloid leukemia (AML) patient after transfusion with HAV contaminated platelets. The patient has been vaccinated against HAV years before the AML diagnosis. Transient infection and reshedding should thus be considered in antibody-positive hematological patients. Transfusion associated HAV transmission is rare, and little evidence exists on the clinical consequences and possible effect of treatment with immunoglobulin. Further reporting on fecal shedding despite antibodies are needed, as HAV antibody levels are used as course of action for post-exposure prophylaxis and infection control.
AB - We describe a rare case of hepatitis A virus (HAV) replication in feces despite presence of hepatitis A antibodies in an acute myeloid leukemia (AML) patient after transfusion with HAV contaminated platelets. The patient has been vaccinated against HAV years before the AML diagnosis. Transient infection and reshedding should thus be considered in antibody-positive hematological patients. Transfusion associated HAV transmission is rare, and little evidence exists on the clinical consequences and possible effect of treatment with immunoglobulin. Further reporting on fecal shedding despite antibodies are needed, as HAV antibody levels are used as course of action for post-exposure prophylaxis and infection control.
U2 - 10.1016/j.jiac.2018.01.020
DO - 10.1016/j.jiac.2018.01.020
M3 - Journal article
C2 - 29490881
SN - 1341-321X
VL - 24
SP - 766
EP - 768
JO - Journal of Infection and Chemotherapy
JF - Journal of Infection and Chemotherapy
IS - 9
ER -
