TY - JOUR
T1 - Transfer of amoxicillin to suckling mink (Neovison vison) kits via the milk from dams treated orally or intra-muscularly
AU - Birch, Julie Melsted
AU - Frandsen, Henrik Lauritz
AU - Struve, Tina
AU - Agger, Jens Frederik
AU - Jensen, Henrik Elvang
PY - 2019
Y1 - 2019
N2 - Treatment of mink kits with pre-weaning diarrhea (PWD) can be time-consuming and expensive for the farmer, and the efficacy of the treatment procedure may be questioned. Evidence-based treatment protocols for application on affected animals at farms with outbreaks of PWD are lacking. In Denmark, the dams are sometimes treated with amoxicillin, however, it is unknown if it is passed on to the mink kits via the milk. The aim of the present study was to investigate if amoxicillin is transferred via the milk to the kits after oral (PO) and intramuscular (IM) treatment, respectively, of the dam. Moreover, we estimated the concentrations of amoxicillin continuously in serum from the kits up to 8 h after administration. The concentration of amoxicillin was not affected by the route of administration (P =.64) and serum reached the highest level after 8 h (34 ng/mL, CI95% = [24.3–47.7]). The serum concentrations of amoxicillin in the mink kits achieved within 8 h were judged too low to exert antimicrobial impact on relevant bacterial species.
AB - Treatment of mink kits with pre-weaning diarrhea (PWD) can be time-consuming and expensive for the farmer, and the efficacy of the treatment procedure may be questioned. Evidence-based treatment protocols for application on affected animals at farms with outbreaks of PWD are lacking. In Denmark, the dams are sometimes treated with amoxicillin, however, it is unknown if it is passed on to the mink kits via the milk. The aim of the present study was to investigate if amoxicillin is transferred via the milk to the kits after oral (PO) and intramuscular (IM) treatment, respectively, of the dam. Moreover, we estimated the concentrations of amoxicillin continuously in serum from the kits up to 8 h after administration. The concentration of amoxicillin was not affected by the route of administration (P =.64) and serum reached the highest level after 8 h (34 ng/mL, CI95% = [24.3–47.7]). The serum concentrations of amoxicillin in the mink kits achieved within 8 h were judged too low to exert antimicrobial impact on relevant bacterial species.
KW - Intra-muscular
KW - Lactation period
KW - Oral
KW - Pharmacokinetics
KW - Pre-weaning diarrhea
KW - Sticky kits
U2 - 10.1016/j.rvsc.2018.12.008
DO - 10.1016/j.rvsc.2018.12.008
M3 - Journal article
C2 - 30586651
AN - SCOPUS:85058800701
SN - 0034-5288
VL - 123
SP - 47
EP - 50
JO - Research in Veterinary Science
JF - Research in Veterinary Science
ER -
