Transcriptional regulation by Polycomb group proteins

TY - JOUR

T1 - Transcriptional regulation by Polycomb group proteins

AU - Di Croce, Luciano

AU - Helin, Kristian

PY - 2013/10

Y1 - 2013/10

N2 - Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease. Mechanistically, they function within multiprotein complexes, called Polycomb repressive complexes (PRCs), which modify histones (and other proteins) and silence target genes. The dynamics of PRC1 and PRC2 components has been the focus of recent research. Here we discuss our current knowledge of the PRC complexes, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.

AB - Polycomb group (PcG) proteins are epigenetic regulators of transcription that have key roles in stem-cell identity, differentiation and disease. Mechanistically, they function within multiprotein complexes, called Polycomb repressive complexes (PRCs), which modify histones (and other proteins) and silence target genes. The dynamics of PRC1 and PRC2 components has been the focus of recent research. Here we discuss our current knowledge of the PRC complexes, how they are targeted to chromatin and how the high diversity of the PcG proteins allows these complexes to influence cell identity.

KW - Animals

KW - Cell Differentiation

KW - Chromatin

KW - Embryonic Stem Cells

KW - Evolution, Molecular

KW - Gene Expression Profiling

KW - Humans

KW - Polycomb-Group Proteins

KW - Transcription, Genetic

U2 - 10.1038/nsmb.2669

DO - 10.1038/nsmb.2669

M3 - Review

C2 - 24096405

SN - 1545-9993

VL - 20

SP - 1147

EP - 1155

JO - Nature Structural and Molecular Biology

JF - Nature Structural and Molecular Biology

IS - 10

ER -