Towards the understanding of complex fluids in pharmaceutical sciences

Pernille Barbre Pedersen; Jari Pekka Pajander; Anette Müllertz; Peter Vilmann; Lene Jørgensen; Stefania G. Baldursdottir

Towards the understanding of complex fluids in pharmaceutical sciences

Pernille Barbre Pedersen, Jari Pekka Pajander, Anette Müllertz, Peter Vilmann, Lene Jørgensen, Stefania G. Baldursdottir

1 Citationer (Scopus)

Abstract

Macromolecular substances are included in most pharmaceutical dosage forms. Their physicochemical properties are important for the performance of the end product, and thus rheological behavior becomes a critical quality attribute. Rheology is a well-known method in the food industry and the characterization of various drug delivery systems by the utilization of rheology could also be beneficial. Additionally, the complexity of the body fluids that the dosage forms come in contact with, e.g. the physicochemical properties like rheological parameters, will affect the therapeutic outcome. This review provides a brief introduction to rheology as a characterization tool and gives examples of the utilization of rheology within the characterization of biological fluids, solid dosage forms and protein formulations. In all those examples rheology has shown to give additional useful information on the conditions experienced by the active pharmaceutical ingredient.

Originalsprog	Engelsk
Tidsskrift	Journal of Drug Delivery Science and Technology
Vol/bind	23
Udgave nummer	4
Sider (fra-til)	393
Antal sider	401
ISSN	1773-2247
Status	Udgivet - 2013

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http://www.sciencedirect.com/science/article/pii/S1773224713500566

Citationsformater

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abstract = "Macromolecular substances are included in most pharmaceutical dosage forms. Their physicochemical properties are important for the performance of the end product, and thus rheological behavior becomes a critical quality attribute. Rheology is a well-known method in the food industry and the characterization of various drug delivery systems by the utilization of rheology could also be beneficial. Additionally, the complexity of the body fluids that the dosage forms come in contact with, e.g. the physicochemical properties like rheological parameters, will affect the therapeutic outcome. This review provides a brief introduction to rheology as a characterization tool and gives examples of the utilization of rheology within the characterization of biological fluids, solid dosage forms and protein formulations. In all those examples rheology has shown to give additional useful information on the conditions experienced by the active pharmaceutical ingredient.",

author = "Pedersen, {Pernille Barbre} and {Pekka Pajander}, Jari and Anette M{\"u}llertz and Peter Vilmann and Lene J{\o}rgensen and Baldursdottir, {Stefania G.}",

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TY - JOUR

T1 - Towards the understanding of complex fluids in pharmaceutical sciences

AU - Pedersen, Pernille Barbre

AU - Pekka Pajander, Jari

AU - Müllertz, Anette

AU - Vilmann, Peter

AU - Jørgensen, Lene

AU - Baldursdottir, Stefania G.

PY - 2013

Y1 - 2013

N2 - Macromolecular substances are included in most pharmaceutical dosage forms. Their physicochemical properties are important for the performance of the end product, and thus rheological behavior becomes a critical quality attribute. Rheology is a well-known method in the food industry and the characterization of various drug delivery systems by the utilization of rheology could also be beneficial. Additionally, the complexity of the body fluids that the dosage forms come in contact with, e.g. the physicochemical properties like rheological parameters, will affect the therapeutic outcome. This review provides a brief introduction to rheology as a characterization tool and gives examples of the utilization of rheology within the characterization of biological fluids, solid dosage forms and protein formulations. In all those examples rheology has shown to give additional useful information on the conditions experienced by the active pharmaceutical ingredient.

AB - Macromolecular substances are included in most pharmaceutical dosage forms. Their physicochemical properties are important for the performance of the end product, and thus rheological behavior becomes a critical quality attribute. Rheology is a well-known method in the food industry and the characterization of various drug delivery systems by the utilization of rheology could also be beneficial. Additionally, the complexity of the body fluids that the dosage forms come in contact with, e.g. the physicochemical properties like rheological parameters, will affect the therapeutic outcome. This review provides a brief introduction to rheology as a characterization tool and gives examples of the utilization of rheology within the characterization of biological fluids, solid dosage forms and protein formulations. In all those examples rheology has shown to give additional useful information on the conditions experienced by the active pharmaceutical ingredient.

M3 - Journal article

SN - 1773-2247

VL - 23

SP - 393

JO - Journal of Drug Delivery Science and Technology

JF - Journal of Drug Delivery Science and Technology

IS - 4

ER -

Towards the understanding of complex fluids in pharmaceutical sciences

Abstract

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