Towards discovery-driven translational research in breast cancer

TY - JOUR

T1 - Towards discovery-driven translational research in breast cancer

AU - Celis, Julio E.

AU - Moreira, José M.A.

AU - Gromova, Irina

AU - Cabezon, Teresa

AU - Ralfkiaer, Ulrik

AU - Guldberg, Per

AU - Thor Straten, Per

AU - Mouridsen, Henning

AU - Friis, Esbern

AU - Holm, Dorte

AU - Rank, Fritz

AU - Gromov, Pavel

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Discovery-driven translational research in breast cancer is moving steadily from the study of cell lines to the analysis of clinically relevant samples that, together with the ever increasing number of novel and powerful technologies available within genomics, proteomics and functional genomics, promise to have a major impact on the way breast cancer will be diagnosed, treated and monitored in the future. Here we present a brief report on long-term ongoing strategies at the Danish Centre for Translational Breast Cancer Research to search for markers for early detection and targets for therapeutic intervention, to identify signalling pathways affected in individual tumours, as well as to integrate multiplatform 'omic' data sets collected from tissue samples obtained from individual patients. The ultimate goal of this initiative is to coalesce knowledge-based complementary procedures into a systems biology approach to fight breast cancer.

AB - Discovery-driven translational research in breast cancer is moving steadily from the study of cell lines to the analysis of clinically relevant samples that, together with the ever increasing number of novel and powerful technologies available within genomics, proteomics and functional genomics, promise to have a major impact on the way breast cancer will be diagnosed, treated and monitored in the future. Here we present a brief report on long-term ongoing strategies at the Danish Centre for Translational Breast Cancer Research to search for markers for early detection and targets for therapeutic intervention, to identify signalling pathways affected in individual tumours, as well as to integrate multiplatform 'omic' data sets collected from tissue samples obtained from individual patients. The ultimate goal of this initiative is to coalesce knowledge-based complementary procedures into a systems biology approach to fight breast cancer.

KW - Breast cancer

KW - Functional genomics

KW - Individualised medicine

KW - Proteomics

KW - Signaling pathways

KW - Systems biology

KW - Translational research

UR - http://www.scopus.com/inward/record.url?scp=19944430032&partnerID=8YFLogxK

U2 - 10.1111/j.1432-1033.2004.04418.x

DO - 10.1111/j.1432-1033.2004.04418.x

M3 - Review

C2 - 15634327

AN - SCOPUS:19944430032

SN - 1742-4658

VL - 272

SP - 2

EP - 15

JO - The F E B S Journal (Online)

JF - The F E B S Journal (Online)

IS - 1

ER -