Towards a reliable animal model of migraine

Jes Olesen; Inger Jansen-Olesen

doi:10.1177/0333102412441719

Towards a reliable animal model of migraine

Jes Olesen, Inger Jansen-Olesen

20 Citationer (Scopus)

Abstract

The pharmaceutical industry shows a decreasing interest in the development of drugs for migraine. One of the reasons for this could be the lack of reliable animal models for studying the effect of acute and prophylactic migraine drugs. The infusion of glyceryl trinitrate (GTN) is the best validated and most studied human migraine model. Several attempts have been made to transfer this model to animals. The different variants of this model are discussed as well as other recent models.

Originalsprog	Engelsk
Tidsskrift	Cephalalgia
Vol/bind	32
Udgave nummer	7
Sider (fra-til)	578-80
Antal sider	3
ISSN	0333-1024
DOI	https://doi.org/10.1177/0333102412441719
Status	Udgivet - maj 2012

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10.1177/0333102412441719

Citationsformater

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AB - The pharmaceutical industry shows a decreasing interest in the development of drugs for migraine. One of the reasons for this could be the lack of reliable animal models for studying the effect of acute and prophylactic migraine drugs. The infusion of glyceryl trinitrate (GTN) is the best validated and most studied human migraine model. Several attempts have been made to transfer this model to animals. The different variants of this model are discussed as well as other recent models.

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Towards a reliable animal model of migraine

Abstract

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