Abstract
This Perspective recapitulates recent developments of carbon dioxide utilization in carbon-carbon bond formation reactions, with an intention of paving a way toward sustainable CO 2 -functionalization and its tangible applications in synthetic chemistry. CO 2 functionalization reactions possess intrinsic drawbacks: the high kinetic inertness and thermodynamic stability of CO 2 . Numerous procedures for CO 2 utilization depend on energy-intensive processes (i.e. high pressure and/or temperature), often solely relying on reactive substrates, hampering its general applications. Recent efforts thus have been dedicated to catalytic CO 2 -utilization under ambient reaction conditions, however, it is still limited to a few activation modes and the use of reactive substrates. Herein, ideal CO 2 -functionalization with particular emphasis on sustainability will be discussed based on the following sub-categories; (1) metal-catalyzed ‘reductive' carboxylation reaction of halides, olefins and allyl alcohols, (2) photochemical CO 2 -utilization, (3) redox-neutral CO 2 -functionalization, and (4) enantioselective catalysis incorporating CO 2 to form C-CO 2 bonds (excluding strain mediated reactions with epoxide- and aziridine-based substrates). Recent progress in these fields will be discussed with the proposed reaction mechanisms and selected examples, highlighting redox-neutral, umpolung, and asymmetric carboxylation to postulate ideal CO 2 functionalization reactions to be developed in the near future.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Chemical Science |
| Vol/bind | 10 |
| Udgave nummer | 14 |
| Sider (fra-til) | 3905-3926 |
| Antal sider | 22 |
| ISSN | 2041-6520 |
| DOI | |
| Status | Udgivet - 2019 |