Topical negative pressure effects on coronary blood flow in a sternal wound model

TY - JOUR

T1 - Topical negative pressure effects on coronary blood flow in a sternal wound model

AU - Lindstedt, Sandra

AU - Malmsjö, Malin

AU - Gesslein, Bodil

AU - Ingemansson, Richard

PY - 2008/10

Y1 - 2008/10

N2 - Several studies have suggested that mediastinitis is a strong predictor for poor long-term survival after coronary artery bypass surgery (CABG). In those studies, several conventional wound-healing techniques were used. Previously, we have shown no difference in long-term survival between CABG patients with topical negative pressure (TNP)-treated mediastinitis and CABG patients without mediastinitis. The present study was designed to elucidate if TNP, applied over the myocardium, resulted in an increase of the total amount of coronary blood flow. Six pigs underwent median sternotomy. The coronary blood flow was measured, before and after the application of TNP (-50 mmHg), using coronary electromagnetic flow meter probes. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 minutes of LAD occlusion (ischaemic myocardium). Normal myocardium: 171.3 +/- 14.5 ml/minute before to 206.3 +/- 17.6 ml/minute after TNP application, P <0.05. Ischaemic myocardium: 133.7 +/- 18.4 ml/minute before to 183.2 +/- 18.9 ml/minute after TNP application, P <0.05. TNP of -50 mmHg applied over the LAD region induced a significant increase in the total coronary blood flow in both normal and ischaemic myocardium.

AB - Several studies have suggested that mediastinitis is a strong predictor for poor long-term survival after coronary artery bypass surgery (CABG). In those studies, several conventional wound-healing techniques were used. Previously, we have shown no difference in long-term survival between CABG patients with topical negative pressure (TNP)-treated mediastinitis and CABG patients without mediastinitis. The present study was designed to elucidate if TNP, applied over the myocardium, resulted in an increase of the total amount of coronary blood flow. Six pigs underwent median sternotomy. The coronary blood flow was measured, before and after the application of TNP (-50 mmHg), using coronary electromagnetic flow meter probes. Analyses were performed before left anterior descending artery (LAD) occlusion (normal myocardium) and after 20 minutes of LAD occlusion (ischaemic myocardium). Normal myocardium: 171.3 +/- 14.5 ml/minute before to 206.3 +/- 17.6 ml/minute after TNP application, P <0.05. Ischaemic myocardium: 133.7 +/- 18.4 ml/minute before to 183.2 +/- 18.9 ml/minute after TNP application, P <0.05. TNP of -50 mmHg applied over the LAD region induced a significant increase in the total coronary blood flow in both normal and ischaemic myocardium.

KW - Animals

KW - Blood Flow Velocity

KW - Coronary Artery Bypass

KW - Coronary Circulation

KW - Disease Models, Animal

KW - Electromagnetic Phenomena

KW - Female

KW - Granulation Tissue

KW - Hemorheology

KW - Laser-Doppler Flowmetry

KW - Male

KW - Mediastinitis

KW - Myocardial Ischemia

KW - Negative-Pressure Wound Therapy

KW - Sternum

KW - Swine

KW - Wound Healing

U2 - 10.1111/j.1742-481X.2008.00429.x

DO - 10.1111/j.1742-481X.2008.00429.x

M3 - Journal article

C2 - 19006573

SN - 1742-4801

VL - 5

SP - 503

EP - 509

JO - International Wound Journal

JF - International Wound Journal

IS - 4

ER -