Tissue engineering of cartilages using biomatrices

TY - JOUR

T1 - Tissue engineering of cartilages using biomatrices

AU - Melrose, James

AU - Chuang, Christine

AU - Whitelock, John

N1 - Cited By :13 Export Date: 24 June 2016 References: Ingber, D.E., Mow, V.C., Butler, D., Niklason, L., Huard, J., Mao, J., Tissue engineering and developmental biology: Going biomimetic (2006) Tissue Eng, 12, pp. 3265-3283; Ornitz, D.M., FGF signaling in the developing endochondral skeleton (2005) Cytokine Growth Factor Rev, 16, pp. 205-213; Melrose, J., Smith, S., Ghosh, P., Whitelock, J., Perlecan, the multidomain heparan sulfate proteoglycan of basement membranes, is also a prominent component of the cartilaginous primordia in the developing human fetal spine (2003) J Histochem Cytochem, 51, pp. 1331-1341; Melrose, J., Smith, S., Knox, S., Whitelock, J., Perlecan, the multidomain HS-proteoglycan of basement membranes, is a prominent pericellular component of ovine hypertrophic vertebral growth plate and cartilaginous endplate chondrocytes (2002) Histochem Cell Biol, 118, pp. 269-280; Melrose, J., Smith, S., Whitelock, J., Perlecan immunolocalises to perichondral vessels and canals in human foetal cartilagenous promordia in early vascular and matrix remodelling events associated with diarthrodial-joint development (2004) J Histochem Cytochem, 52, pp. 1405-1413; Denker, A.E., Haas, A.R., Nicoll, S.B., Tuan, R.S., Chondrogenic differentiation of murine C3H10T1/2 multipotential mesenchymal cells. 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PY - 2008

Y1 - 2008

N2 - Tissue engineering is an exciting new cross-disciplinary methodology which applies the principles of engineering and structure-function relationships between normal and pathological tissues to develop biological substitute to restore, maintain or improve tissue function. Tissue engineering therefore involves a melange of approaches encompassing developmental biology, tissue mechanics, medicine, cell differentiation and survival biology, mechanostransduction and nano-fabrication technology. The central tissue of interest in this review is cartilage. Traumatic injuries, congenital abnormalities and age-related degenerative diseases can all lead to cartilage loss; however, the low cell density and very limited self-renewal capacity of cartilage necessitate the development of effective therapeutic repair strategies for this tissue. The ontogeny of the chondrocyte, which is the cell that provides the biosynthetic machinery for all the component parts of cartilage, is discussed, since an understanding of cartilage development is central to the maintenance of a chondrocytic phenotype in any strategy aiming to produce a replacement cartilage. A plethora of matrices have been developed for cartilage engineering approaches and many of these are discussed and their in vitro and in vivo applications covered in this review. Tissue engineering is entering an exciting era; significant advances have been made; however, many technical challenges remain to be solved before this technology becomes widely applicable across all areas of cartilage repair biology. © 2008 Society of Chemical Industry.

AB - Tissue engineering is an exciting new cross-disciplinary methodology which applies the principles of engineering and structure-function relationships between normal and pathological tissues to develop biological substitute to restore, maintain or improve tissue function. Tissue engineering therefore involves a melange of approaches encompassing developmental biology, tissue mechanics, medicine, cell differentiation and survival biology, mechanostransduction and nano-fabrication technology. The central tissue of interest in this review is cartilage. Traumatic injuries, congenital abnormalities and age-related degenerative diseases can all lead to cartilage loss; however, the low cell density and very limited self-renewal capacity of cartilage necessitate the development of effective therapeutic repair strategies for this tissue. The ontogeny of the chondrocyte, which is the cell that provides the biosynthetic machinery for all the component parts of cartilage, is discussed, since an understanding of cartilage development is central to the maintenance of a chondrocytic phenotype in any strategy aiming to produce a replacement cartilage. A plethora of matrices have been developed for cartilage engineering approaches and many of these are discussed and their in vitro and in vivo applications covered in this review. Tissue engineering is entering an exciting era; significant advances have been made; however, many technical challenges remain to be solved before this technology becomes widely applicable across all areas of cartilage repair biology. © 2008 Society of Chemical Industry.

KW - Cartilage

KW - Chondrocytes

KW - Matrices

KW - Tissue engineering

U2 - 10.1002/jctb.1857

DO - 10.1002/jctb.1857

M3 - Journal article

SN - 0268-2575

VL - 83

SP - 444

EP - 463

JO - Journal of Chemical Technology and Biotechnology

JF - Journal of Chemical Technology and Biotechnology

IS - 4

ER -