TY - JOUR
T1 - Time to Explore Transcatheter Aortic Valve Replacement in Younger, Low-Risk Patients
AU - Sondergaard, Lars
PY - 2016/11/14
Y1 - 2016/11/14
N2 - During the last decade transcatheter aortic valve replacement (TAVR) has been established as a treatment for patients with severe aortic stenosis, who are at particularly high surgical risk. As compared with surgical aortic valve replacement (SAVR), TAVR has been associated with lower early risk of mortality, atrial fibrillation, acute kidney injury, and bleeding. Furthermore, device and periprocedural improvements have addressed most of the initial limitations for TAVR, including the Achilles’ heel, paravalvular leakage. Supported by this as well as preliminary data among lower-risk patients, TAVR is currently being evaluated in prospective randomized trials against SAVR in younger low-risk patients. Although durability of the TAVR device may be of concern in younger patients given their longer life expectancy, intermediate-term controlled data does not reveal any difference between TAVR and SAVR devices.
AB - During the last decade transcatheter aortic valve replacement (TAVR) has been established as a treatment for patients with severe aortic stenosis, who are at particularly high surgical risk. As compared with surgical aortic valve replacement (SAVR), TAVR has been associated with lower early risk of mortality, atrial fibrillation, acute kidney injury, and bleeding. Furthermore, device and periprocedural improvements have addressed most of the initial limitations for TAVR, including the Achilles’ heel, paravalvular leakage. Supported by this as well as preliminary data among lower-risk patients, TAVR is currently being evaluated in prospective randomized trials against SAVR in younger low-risk patients. Although durability of the TAVR device may be of concern in younger patients given their longer life expectancy, intermediate-term controlled data does not reveal any difference between TAVR and SAVR devices.
KW - aortic stenosis
KW - risk
KW - SAVR
KW - TAVR
U2 - 10.1016/j.jcin.2016.08.015
DO - 10.1016/j.jcin.2016.08.015
M3 - Review
C2 - 27744040
AN - SCOPUS:84994389301
SN - 1936-8798
VL - 9
SP - 2183
EP - 2185
JO - J A C C: Cardiovascular Interventions
JF - J A C C: Cardiovascular Interventions
IS - 21
ER -