Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high-fat fed mice

TY - JOUR

T1 - Thylakoids suppress appetite by increasing cholecystokinin resulting in lower food intake and body weight in high-fat fed mice

AU - Köhnke, Rickard

AU - Lindqvist, Andreas

AU - Göransson, Nathanael

AU - Emek, Sinan C

AU - Albertsson, Per-Ake

AU - Rehfeld, Jens F

AU - Hultgårdh-Nilsson, Anna

AU - Erlanson-Albertsson, Charlotte

N1 - Keywords: Adipose Tissue; Animals; Appetite; Appetite Depressants; Blood Glucose; Body Weight; Chlorophyll; Cholecystokinin; Dietary Fats; Eating; Fatty Acids; Female; Leptin; Lipase; Mice; Mice, Knockout; Satiety Response; Spinacia oleracea; Thylakoids; Triglycerides

PY - 2009

Y1 - 2009

N2 - Thylakoids are membranes isolated from plant chloroplasts which have previously been shown to inhibit pancreatic lipase/colipase catalysed hydrolysis of fat in vitro and induce short-term satiety in vivo. The purpose of the present study was to examine if dietary supplementation of thylakoids could affect food intake and body weight during long-term feeding in mice. Female apolipoprotein E-deficient mice were fed a high-fat diet containing 41% of fat by energy with and without thylakoids for 100 days. Mice fed the thylakoid-enriched diet had suppressed food intake, body weight gain and body fat compared with the high-fat fed control mice. Reduced serum glucose, serum triglyceride and serum free fatty acid levels were found in the thylakoid-treated animals. The satiety hormone cholecystokinin was elevated, suggesting this hormone mediates satiety. Leptin levels were reduced, reflecting a decreased fat mass. There was no sign of desensitization in the animals treated with thylakoids. The results suggest that thylakoids are useful to suppress appetite and body weight gain when supplemented to a high-fat food during long-term feeding.

AB - Thylakoids are membranes isolated from plant chloroplasts which have previously been shown to inhibit pancreatic lipase/colipase catalysed hydrolysis of fat in vitro and induce short-term satiety in vivo. The purpose of the present study was to examine if dietary supplementation of thylakoids could affect food intake and body weight during long-term feeding in mice. Female apolipoprotein E-deficient mice were fed a high-fat diet containing 41% of fat by energy with and without thylakoids for 100 days. Mice fed the thylakoid-enriched diet had suppressed food intake, body weight gain and body fat compared with the high-fat fed control mice. Reduced serum glucose, serum triglyceride and serum free fatty acid levels were found in the thylakoid-treated animals. The satiety hormone cholecystokinin was elevated, suggesting this hormone mediates satiety. Leptin levels were reduced, reflecting a decreased fat mass. There was no sign of desensitization in the animals treated with thylakoids. The results suggest that thylakoids are useful to suppress appetite and body weight gain when supplemented to a high-fat food during long-term feeding.

U2 - 10.1002/ptr.2855

DO - 10.1002/ptr.2855

M3 - Journal article

C2 - 19548286

SN - 0951-418X

VL - 23

SP - 1778

EP - 1783

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 12

ER -