Thrombolytic and anticoagulation treatment in a rat embolic stroke model

Rune Skovgaard Rasmussen; K Overgaard; P Meden; G Boysen

Thrombolytic and anticoagulation treatment in a rat embolic stroke model

Rune Skovgaard Rasmussen, K Overgaard, P Meden, G Boysen

6 Citationer (Scopus)

Abstract

OBJECTIVES: The effects of pentasaccharide (PENTA), given alone or combined with thrombolysis using recombinant tissue plasminogen activator (rt-PA), on infarct size and clinical outcome were evaluated in a rat embolic stroke model.

MATERIALS AND METHODS: Ninety-two rats were embolized unilaterally and assigned to: (i). controls, (ii). rt-PA 6 mg/kg, (iii). PENTA 0.5 mg/kg, (iv). PENTA 0.5 mg/kg and rt-PA 6 mg/kg. After 2 days animals were killed, the brains removed and evaluated microscopically.

RESULTS: The median infarct size measured in percentage of the affected hemisphere was 25% in the control group, 4% (P < 0.01, Mann Whitney) in group 2, 19% (n.s.) in group 3, and 10% (P < 0.05) in group 4. rt-PA, and rt-PA combined with PENTA also promoted functional recovery.

CONCLUSION: The present study found no effect of 0.5 mg/kg PENTA treatment. Compared with rt-PA treatment alone, 0.5 mg/kg PENTA alone or combined with rt-PA did not significantly increase mortality or tendency for hemorrhage.

Originalsprog	Engelsk
Tidsskrift	Acta Neurologica Scandinavica
Vol/bind	108
Udgave nummer	3
Sider (fra-til)	185-92
Antal sider	8
ISSN	0001-6314
Status	Udgivet - sep. 2003

Citationsformater

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title = "Thrombolytic and anticoagulation treatment in a rat embolic stroke model",

abstract = "OBJECTIVES: The effects of pentasaccharide (PENTA), given alone or combined with thrombolysis using recombinant tissue plasminogen activator (rt-PA), on infarct size and clinical outcome were evaluated in a rat embolic stroke model.MATERIALS AND METHODS: Ninety-two rats were embolized unilaterally and assigned to: (i). controls, (ii). rt-PA 6 mg/kg, (iii). PENTA 0.5 mg/kg, (iv). PENTA 0.5 mg/kg and rt-PA 6 mg/kg. After 2 days animals were killed, the brains removed and evaluated microscopically.RESULTS: The median infarct size measured in percentage of the affected hemisphere was 25% in the control group, 4% (P < 0.01, Mann Whitney) in group 2, 19% (n.s.) in group 3, and 10% (P < 0.05) in group 4. rt-PA, and rt-PA combined with PENTA also promoted functional recovery.CONCLUSION: The present study found no effect of 0.5 mg/kg PENTA treatment. Compared with rt-PA treatment alone, 0.5 mg/kg PENTA alone or combined with rt-PA did not significantly increase mortality or tendency for hemorrhage.",

keywords = "Angiography, Animals, Anticoagulants, Disease Models, Animal, Drug Therapy, Combination, Fibrinolytic Agents, Intracranial Embolism, Male, Oligosaccharides, Plasminogen Activators, Rats, Rats, Sprague-Dawley, Stroke, Thrombolytic Therapy",

author = "Rasmussen, {Rune Skovgaard} and K Overgaard and P Meden and G Boysen",

year = "2003",

month = sep,

language = "English",

volume = "108",

pages = "185--92",

journal = "Acta Neurologica Scandinavica",

issn = "0001-6314",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Thrombolytic and anticoagulation treatment in a rat embolic stroke model

AU - Rasmussen, Rune Skovgaard

AU - Overgaard, K

AU - Meden, P

AU - Boysen, G

PY - 2003/9

Y1 - 2003/9

N2 - OBJECTIVES: The effects of pentasaccharide (PENTA), given alone or combined with thrombolysis using recombinant tissue plasminogen activator (rt-PA), on infarct size and clinical outcome were evaluated in a rat embolic stroke model.MATERIALS AND METHODS: Ninety-two rats were embolized unilaterally and assigned to: (i). controls, (ii). rt-PA 6 mg/kg, (iii). PENTA 0.5 mg/kg, (iv). PENTA 0.5 mg/kg and rt-PA 6 mg/kg. After 2 days animals were killed, the brains removed and evaluated microscopically.RESULTS: The median infarct size measured in percentage of the affected hemisphere was 25% in the control group, 4% (P < 0.01, Mann Whitney) in group 2, 19% (n.s.) in group 3, and 10% (P < 0.05) in group 4. rt-PA, and rt-PA combined with PENTA also promoted functional recovery.CONCLUSION: The present study found no effect of 0.5 mg/kg PENTA treatment. Compared with rt-PA treatment alone, 0.5 mg/kg PENTA alone or combined with rt-PA did not significantly increase mortality or tendency for hemorrhage.

AB - OBJECTIVES: The effects of pentasaccharide (PENTA), given alone or combined with thrombolysis using recombinant tissue plasminogen activator (rt-PA), on infarct size and clinical outcome were evaluated in a rat embolic stroke model.MATERIALS AND METHODS: Ninety-two rats were embolized unilaterally and assigned to: (i). controls, (ii). rt-PA 6 mg/kg, (iii). PENTA 0.5 mg/kg, (iv). PENTA 0.5 mg/kg and rt-PA 6 mg/kg. After 2 days animals were killed, the brains removed and evaluated microscopically.RESULTS: The median infarct size measured in percentage of the affected hemisphere was 25% in the control group, 4% (P < 0.01, Mann Whitney) in group 2, 19% (n.s.) in group 3, and 10% (P < 0.05) in group 4. rt-PA, and rt-PA combined with PENTA also promoted functional recovery.CONCLUSION: The present study found no effect of 0.5 mg/kg PENTA treatment. Compared with rt-PA treatment alone, 0.5 mg/kg PENTA alone or combined with rt-PA did not significantly increase mortality or tendency for hemorrhage.

KW - Angiography

KW - Animals

KW - Anticoagulants

KW - Disease Models, Animal

KW - Drug Therapy, Combination

KW - Fibrinolytic Agents

KW - Intracranial Embolism

KW - Male

KW - Oligosaccharides

KW - Plasminogen Activators

KW - Rats

KW - Rats, Sprague-Dawley

KW - Stroke

KW - Thrombolytic Therapy

M3 - Journal article

C2 - 12911462

SN - 0001-6314

VL - 108

SP - 185

EP - 192

JO - Acta Neurologica Scandinavica

JF - Acta Neurologica Scandinavica

IS - 3

ER -

Thrombolytic and anticoagulation treatment in a rat embolic stroke model

Abstract

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