Three-step synthesis of (Thio)xanthene and Dibenzothiepine/Dibenzoxepine by an intramolecular mizoroki–heck reaction of Diaryl (Thio)ethers

Tue Heesgaard Jepsen; Mogens Larsen; Morten Jørgensen; Mogens Brøndsted Nielsen

doi:10.1055/s-0031-1290317

Three-step synthesis of (Thio)xanthene and Dibenzothiepine/Dibenzoxepine by an intramolecular mizoroki–heck reaction of Diaryl (Thio)ethers

Tue Heesgaard Jepsen, Mogens Larsen, Morten Jørgensen, Mogens Brøndsted Nielsen

Kemisk Institut

13 Citationer (Scopus)

Abstract

We present a novel three-step protocol for preparing xanthene/thioxanthene and dibenzothiepine/dibenzoxepine from readily available starting materials. The Mizoroki-Heck cyclization as the final step was optimized to afford full conversion of the corresponding diaryl (thio)ethers and furthermore to achieve reasonably good selectivity between the 6-exo and the 7-endo products.

Originalsprog	Engelsk
Tidsskrift	SYNLETT: Accounts and Rapid Communications in Chemical Synthesis
Udgave nummer	3
Sider (fra-til)	418-422
Antal sider	5
ISSN	0936-5214
DOI	https://doi.org/10.1055/s-0031-1290317
Status	Udgivet - 2012

Adgang til dokumentet

10.1055/s-0031-1290317

Citationsformater

Three-step synthesis of (Thio)xanthene and Dibenzothiepine/Dibenzoxepine by an intramolecular mizoroki–heck reaction of Diaryl (Thio)ethers. / Jepsen, Tue Heesgaard; Larsen, Mogens; Jørgensen, Morten et al.

I: SYNLETT: Accounts and Rapid Communications in Chemical Synthesis, Nr. 3, 2012, s. 418-422.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

@article{e4d43df2fb9e4b6a904160278102c95a,

title = "Three-step synthesis of (Thio)xanthene and Dibenzothiepine/Dibenzoxepine by an intramolecular mizoroki–heck reaction of Diaryl (Thio)ethers",

abstract = "We present a novel three-step protocol for preparing xanthene/thioxanthene and dibenzothiepine/dibenzoxepine from readily available starting materials. The Mizoroki-Heck cyclization as the final step was optimized to afford full conversion of the corresponding diaryl (thio)ethers and furthermore to achieve reasonably good selectivity between the 6-exo and the 7-endo products.",

author = "Jepsen, {Tue Heesgaard} and Mogens Larsen and Morten J{\o}rgensen and Nielsen, {Mogens Br{\o}ndsted}",

year = "2012",

doi = "10.1055/s-0031-1290317",

language = "English",

pages = "418--422",

journal = "Synlett",

issn = "0936-5214",

publisher = "Thieme",

number = "3",

}

TY - JOUR

T1 - Three-step synthesis of (Thio)xanthene and Dibenzothiepine/Dibenzoxepine by an intramolecular mizoroki–heck reaction of Diaryl (Thio)ethers

AU - Jepsen, Tue Heesgaard

AU - Larsen, Mogens

AU - Jørgensen, Morten

AU - Nielsen, Mogens Brøndsted

PY - 2012

Y1 - 2012

N2 - We present a novel three-step protocol for preparing xanthene/thioxanthene and dibenzothiepine/dibenzoxepine from readily available starting materials. The Mizoroki-Heck cyclization as the final step was optimized to afford full conversion of the corresponding diaryl (thio)ethers and furthermore to achieve reasonably good selectivity between the 6-exo and the 7-endo products.

AB - We present a novel three-step protocol for preparing xanthene/thioxanthene and dibenzothiepine/dibenzoxepine from readily available starting materials. The Mizoroki-Heck cyclization as the final step was optimized to afford full conversion of the corresponding diaryl (thio)ethers and furthermore to achieve reasonably good selectivity between the 6-exo and the 7-endo products.

U2 - 10.1055/s-0031-1290317

DO - 10.1055/s-0031-1290317

M3 - Journal article

SN - 0936-5214

SP - 418

EP - 422

JO - Synlett

JF - Synlett

IS - 3

ER -

Three-step synthesis of (Thio)xanthene and Dibenzothiepine/Dibenzoxepine by an intramolecular mizoroki–heck reaction of Diaryl (Thio)ethers

Abstract

Adgang til dokumentet

Fingeraftryk

Citationsformater