Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

Nicolaj Brandt; Lene H Garvey; Ulla Bindslev-Jensen; Henrik Fomsgaard Kjaer; Carsten Bindslev-Jensen; Charlotte G Mortz

doi:10.1186/s13601-016-0138-3

Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

Nicolaj Brandt, Lene H Garvey, Ulla Bindslev-Jensen, Henrik Fomsgaard Kjaer, Carsten Bindslev-Jensen, Charlotte G Mortz

Institut for Klinisk Medicin

4 Citationer (Scopus)

51 Downloads (Pure)

Abstract

We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients.

Originalsprog	Engelsk
Artikelnummer	2
Tidsskrift	Clinical and Translational Allergy
Vol/bind	7
Antal sider	4
ISSN	2045-7022
DOI	https://doi.org/10.1186/s13601-016-0138-3
Status	Udgivet - 10 jan. 2017

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10.1186/s13601-016-0138-3Licens: CC BY

s13601-016-0138-3Forlagets udgivne version, 591 KBLicens: CC BY

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AU - Brandt, Nicolaj

AU - Garvey, Lene H

AU - Bindslev-Jensen, Ulla

AU - Kjaer, Henrik Fomsgaard

AU - Bindslev-Jensen, Carsten

AU - Mortz, Charlotte G

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N2 - We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients.

AB - We present three cases with anaphylaxis after injection of a depot corticosteroid. First, the steroid was suspected as the elicitor, but after evaluation the excipient macrogol was found to be the elicitor. One of the patients had reactions to several unrelated drugs. Increased awareness of anaphylaxis to excipients such as macrogols is needed, especially when allergy tests for the active drug is negative and in patients with a history of repeated anaphylaxis to seemingly unrelated drugs. To establish the correct diagnosis it is important to test with the exact formulation of the culprit drug, as well as all the ingredients including excipients.

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M3 - Comment/debate

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Three cases of anaphylaxis following injection of a depot corticosteroid with evidence of IgE sensitization to macrogols rather than the active steroid

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