Thickness mapping of individual retinal layers and sectors by Spectralis SD‐OCT in Autosomal Dominant Optic Atrophy

Nihada Corajevic; Michael Larsen; Cecilia Rönnbäck

doi:10.1111/aos.13588

Thickness mapping of individual retinal layers and sectors by Spectralis SD‐OCT in Autosomal Dominant Optic Atrophy

Nihada Corajevic, Michael Larsen, Cecilia Rönnbäck

Institut for Klinisk Medicin

7 Citationer (Scopus)

Abstract

Purpose: To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. Methods: This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6–83.5 years; best-corrected visual acuity (BCVA), 8–89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9–68.7; BCVA, 80–99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) and the peripapillary RNFL. Combinations of layers and sectors were tested for their diagnostic significance. Only right eye data are presented. Statistical analysis was adjusted for age, gender, spherical equivalent, axial length and family clustering in a mixed model analysis. Results: The perifoveal RNFL, GCL, IPL and the peripapillary RNFL were all significantly thinner in ADOA patients than in healthy controls (p < 0.0001). No statistical difference was found for other layers. The most prominent and diagnostically most valuable deficit was found in the GCL (−49.9%) in the ‘nasal inner macula’ (NIM) sector (−63%). Attenuation of the peripapillary RNFL was most significant in the temporal sector (−58.4%). Conclusion: In ADOA, retinal ganglion cells are most prominently reduced in the nasal perifoveal area of the GCL, which together with the temporal peripapillary RNFL area serves as the strongest diagnostic OCT marker.

Originalsprog	Engelsk
Tidsskrift	Acta Ophthalmologica
Vol/bind	96
Udgave nummer	3
Sider (fra-til)	251-256
Antal sider	6
ISSN	1755-375X
DOI	https://doi.org/10.1111/aos.13588
Status	Udgivet - maj 2018

FN’s Verdensmål

Dette resultat bidrager til følgende verdensmål

Adgang til dokumentet

10.1111/aos.13588

aos.13588Forlagets udgivne version, 372 KB

Citationsformater

@article{2dff458bd70744768d6cd01e6d417c7f,

title = "Thickness mapping of individual retinal layers and sectors by Spectralis SD‐OCT in Autosomal Dominant Optic Atrophy",

abstract = "Purpose: To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. Methods: This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6–83.5 years; best-corrected visual acuity (BCVA), 8–89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9–68.7; BCVA, 80–99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) and the peripapillary RNFL. Combinations of layers and sectors were tested for their diagnostic significance. Only right eye data are presented. Statistical analysis was adjusted for age, gender, spherical equivalent, axial length and family clustering in a mixed model analysis. Results: The perifoveal RNFL, GCL, IPL and the peripapillary RNFL were all significantly thinner in ADOA patients than in healthy controls (p < 0.0001). No statistical difference was found for other layers. The most prominent and diagnostically most valuable deficit was found in the GCL (−49.9%) in the {\textquoteleft}nasal inner macula{\textquoteright} (NIM) sector (−63%). Attenuation of the peripapillary RNFL was most significant in the temporal sector (−58.4%). Conclusion: In ADOA, retinal ganglion cells are most prominently reduced in the nasal perifoveal area of the GCL, which together with the temporal peripapillary RNFL area serves as the strongest diagnostic OCT marker.",

keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Child, Chromosomes, Human, Pair 3/genetics, Cross-Sectional Studies, DNA Mutational Analysis, Exons, Female, GTP Phosphohydrolases/genetics, Humans, Macula Lutea/pathology, Male, Middle Aged, Mutation, Nerve Fibers/pathology, Optic Atrophy, Autosomal Dominant/diagnosis, Retinal Ganglion Cells/pathology, Tomography, Optical Coherence/methods, Visual Acuity, Young Adult",

author = "Nihada Corajevic and Michael Larsen and Cecilia R{\"o}nnb{\"a}ck",

note = "{\textcopyright} 2017 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd.",

year = "2018",

month = may,

doi = "10.1111/aos.13588",

language = "English",

volume = "96",

pages = "251--256",

journal = "Acta Ophthalmologica",

issn = "1755-375X",

publisher = "Wiley-Blackwell",

number = "3",

}

TY - JOUR

T1 - Thickness mapping of individual retinal layers and sectors by Spectralis SD‐OCT in Autosomal Dominant Optic Atrophy

AU - Corajevic, Nihada

AU - Larsen, Michael

AU - Rönnbäck, Cecilia

PY - 2018/5

Y1 - 2018/5

N2 - Purpose: To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. Methods: This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6–83.5 years; best-corrected visual acuity (BCVA), 8–89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9–68.7; BCVA, 80–99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) and the peripapillary RNFL. Combinations of layers and sectors were tested for their diagnostic significance. Only right eye data are presented. Statistical analysis was adjusted for age, gender, spherical equivalent, axial length and family clustering in a mixed model analysis. Results: The perifoveal RNFL, GCL, IPL and the peripapillary RNFL were all significantly thinner in ADOA patients than in healthy controls (p < 0.0001). No statistical difference was found for other layers. The most prominent and diagnostically most valuable deficit was found in the GCL (−49.9%) in the ‘nasal inner macula’ (NIM) sector (−63%). Attenuation of the peripapillary RNFL was most significant in the temporal sector (−58.4%). Conclusion: In ADOA, retinal ganglion cells are most prominently reduced in the nasal perifoveal area of the GCL, which together with the temporal peripapillary RNFL area serves as the strongest diagnostic OCT marker.

AB - Purpose: To assess layer- and location-specific retinal thickness deficits in autosomal dominant optic atrophy (ADOA) using Spectralis SD-OCT. Methods: This cross-sectional study included 41 ADOA patients with OPA1 exon 28 (2826delT) mutation [age, 8.6–83.5 years; best-corrected visual acuity (BCVA), 8–89 Early Treatment Diabetic Retinopathy Study (ETDRS) letters] and 55 mutation-free first-degree relatives as healthy controls (age, 8.9–68.7; BCVA, 80–99). Participants underwent routine examination and optical coherence tomography (OCT) with segmentation of the whole retina, inner retinal layers (IRL) and outer retinal layers (ORL). Individual segmentation was performed of the perifoveal retinal nerve fibre layer (RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), inner nuclear layer (INL), outer plexiform layer (OPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE) and the peripapillary RNFL. Combinations of layers and sectors were tested for their diagnostic significance. Only right eye data are presented. Statistical analysis was adjusted for age, gender, spherical equivalent, axial length and family clustering in a mixed model analysis. Results: The perifoveal RNFL, GCL, IPL and the peripapillary RNFL were all significantly thinner in ADOA patients than in healthy controls (p < 0.0001). No statistical difference was found for other layers. The most prominent and diagnostically most valuable deficit was found in the GCL (−49.9%) in the ‘nasal inner macula’ (NIM) sector (−63%). Attenuation of the peripapillary RNFL was most significant in the temporal sector (−58.4%). Conclusion: In ADOA, retinal ganglion cells are most prominently reduced in the nasal perifoveal area of the GCL, which together with the temporal peripapillary RNFL area serves as the strongest diagnostic OCT marker.

KW - Adolescent

KW - Adult

KW - Aged

KW - Aged, 80 and over

KW - Child

KW - Chromosomes, Human, Pair 3/genetics

KW - Cross-Sectional Studies

KW - DNA Mutational Analysis

KW - Exons

KW - Female

KW - GTP Phosphohydrolases/genetics

KW - Humans

KW - Macula Lutea/pathology

KW - Male

KW - Middle Aged

KW - Mutation

KW - Nerve Fibers/pathology

KW - Optic Atrophy, Autosomal Dominant/diagnosis

KW - Retinal Ganglion Cells/pathology

KW - Tomography, Optical Coherence/methods

KW - Visual Acuity

KW - Young Adult

U2 - 10.1111/aos.13588

DO - 10.1111/aos.13588

M3 - Journal article

C2 - 29091347

SN - 1755-375X

VL - 96

SP - 251

EP - 256

JO - Acta Ophthalmologica

JF - Acta Ophthalmologica

IS - 3

ER -

Thickness mapping of individual retinal layers and sectors by Spectralis SD‐OCT in Autosomal Dominant Optic Atrophy

Abstract

FN’s Verdensmål

Adgang til dokumentet

Fingeraftryk

Citationsformater