Therapeutic application of multipotent stem cells

TY - JOUR

T1 - Therapeutic application of multipotent stem cells

AU - Mirzaei, Hamed

AU - Sahebkar, Amirhossein

AU - Sichani, Laleh Shiri

AU - Moridikia, Abdullah

AU - Nazari, Sara

AU - Sadri Nahand, Javid

AU - salehi, Hossein

AU - Stenvang, Jan

AU - Masoudifar, Aria

AU - Mirzaei, Hamid R.

AU - Jaafari, Mahmoud R.

PY - 2018/4

Y1 - 2018/4

N2 - Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self-renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti-inflammatory and anti-apoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications.

AB - Cell therapy is an emerging fields in the treatment of various diseases such as cardiovascular, pulmonary, hepatic, and neoplastic diseases. Stem cells are an integral tool for cell therapy. Multipotent stem cells are an important class of stem cells which have the ability to self-renew through dividing and developing into multiple specific cell types in a specific tissue or organ. These cells are capable to activate or inhibit a sequence of cellular and molecular pathways leading to anti-inflammatory and anti-apoptotic effects which might contribute to the treatment of various diseases. It has been showed that multipotent stem cells exert their therapeutic effects via inhibition/activation of a sequence of cellular and molecular pathways. Although the advantages of multipotent stem cells are numerous, further investigation is still necessary to clarify the biology and safety of these cells before they could be considered as a potential treatment for different types of diseases. This review summarizes different features of multipotent stem cells including isolation, differentiation, and therapeutic applications.

KW - Differentiation

KW - Multipotent stem cells

KW - Therapy

U2 - 10.1002/jcp.25990

DO - 10.1002/jcp.25990

M3 - Review

C2 - 28475219

AN - SCOPUS:85021227833

SN - 0021-9541

VL - 233

SP - 2815

EP - 2823

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

IS - 4

ER -