TY - JOUR
T1 - The use of transrectal ultrasound-guided biopsy following the introduction of prostate-specific antigen testing in Denmark
T2 - a population-based analysis
AU - Klemann, Nina
AU - Røder, Martin Andreas
AU - Helgstrand, John Thomas
AU - Brasso, Klaus
AU - Toft, Birgitte G
AU - Vainer, Ben
AU - Iversen, Peter
PY - 2018/5/4
Y1 - 2018/5/4
N2 - OBJECTIVE: Incidence rates of prostate cancer in Denmark resemble those of countries that endorse prostate-specific antigen (PSA) screening. So far, no studies have described the consequences of PSA testing on diagnostic activity on a population level. The aim of this study was to describe the frequency of systematic transrectal ultrasound-guided biopsy (TRUS-gb) activity, including rebiopsy rates, in Denmark between 1995 and 2011.MATERIALS AND METHODS: All men who underwent TRUS-gb during the period were identified in the Danish Prostate Cancer Registry. In total, 83,041 biopsy sets from 64,430 individuals were identified. The diagnostic rate and the frequency of rebiopsy were analyzed. Age, histology and PSA were compared at the time of biopsy.RESULTS: The number of TRUS-gb per 100,000 men per year increased 4.6-fold. The mean number of TRUS-gb procedures per individual increased from 1.08 in 1995 to 1.46 in 2011 (p = .0001), and the proportion of men with negative initial biopsy sets who underwent rebiopsy increased from 22% in 1995 to 41% in 2004, later decreasing to 31% in 2009.CONCLUSIONS: The diagnostic activity in Denmark and the rebiopsy rates in men with initial negative TRUS-gb have increased substantially, and guidelines for the management of men with a negative initial biopsy are highly warranted.
AB - OBJECTIVE: Incidence rates of prostate cancer in Denmark resemble those of countries that endorse prostate-specific antigen (PSA) screening. So far, no studies have described the consequences of PSA testing on diagnostic activity on a population level. The aim of this study was to describe the frequency of systematic transrectal ultrasound-guided biopsy (TRUS-gb) activity, including rebiopsy rates, in Denmark between 1995 and 2011.MATERIALS AND METHODS: All men who underwent TRUS-gb during the period were identified in the Danish Prostate Cancer Registry. In total, 83,041 biopsy sets from 64,430 individuals were identified. The diagnostic rate and the frequency of rebiopsy were analyzed. Age, histology and PSA were compared at the time of biopsy.RESULTS: The number of TRUS-gb per 100,000 men per year increased 4.6-fold. The mean number of TRUS-gb procedures per individual increased from 1.08 in 1995 to 1.46 in 2011 (p = .0001), and the proportion of men with negative initial biopsy sets who underwent rebiopsy increased from 22% in 1995 to 41% in 2004, later decreasing to 31% in 2009.CONCLUSIONS: The diagnostic activity in Denmark and the rebiopsy rates in men with initial negative TRUS-gb have increased substantially, and guidelines for the management of men with a negative initial biopsy are highly warranted.
KW - Aged
KW - Biopsy, Large-Core Needle/statistics & numerical data
KW - Denmark
KW - Early Detection of Cancer
KW - Endosonography
KW - Humans
KW - Male
KW - Middle Aged
KW - Prostate-Specific Antigen/blood
KW - Prostatic Neoplasms/blood
KW - Registries
KW - Reoperation/statistics & numerical data
KW - Ultrasonography, Interventional
U2 - 10.1080/21681805.2018.1444672
DO - 10.1080/21681805.2018.1444672
M3 - Journal article
C2 - 29514539
SN - 0036-5599
VL - 52
SP - 169
EP - 173
JO - Scandinavian Journal of Urology
JF - Scandinavian Journal of Urology
IS - 3
ER -
