The transport of phosphate between the plasma and dialysate compartments in peritoneal dialysis is influenced by an electric potential difference

J Graff; S Fugleberg; J Brahm; N Fogh-Andersen

The transport of phosphate between the plasma and dialysate compartments in peritoneal dialysis is influenced by an electric potential difference

J Graff, S Fugleberg, J Brahm, N Fogh-Andersen

ICMM Afdeling 8

12 Citationer (Scopus)

Abstract

Six kinetic models of transperitoneal phosphate transport were formulated and validated on the basis of experimental results obtained from 22 non-diabetic patients undergoing peritoneal dialysis. The models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective, and lymphatic convective phosphate transport. Calculations allowed for a 20% protein binding of phosphate. The validation procedure demonstrated that only diffusive and non-lymphatic convective phosphate transport mechanisms were identifiable. A lymphatic convective phosphate transport mechanism was not identifiable. Furthermore, it was demonstrated that the electrochemical gradient between plasma water and dialysate favours the diffusive phosphate transport, and both electric and chemical potentials must be taken into account in calculations of the transperitoneal phosphate transport.

Originalsprog	Engelsk
Tidsskrift	Clinical physiology (Oxford, England)
Vol/bind	16
Udgave nummer	3
Sider (fra-til)	291-300
Antal sider	10
ISSN	0144-5979
Status	Udgivet - maj 1996

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Citationsformater

@article{e5447f2df3b942ccac69f3763533da8b,

title = "The transport of phosphate between the plasma and dialysate compartments in peritoneal dialysis is influenced by an electric potential difference",

abstract = "Six kinetic models of transperitoneal phosphate transport were formulated and validated on the basis of experimental results obtained from 22 non-diabetic patients undergoing peritoneal dialysis. The models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective, and lymphatic convective phosphate transport. Calculations allowed for a 20% protein binding of phosphate. The validation procedure demonstrated that only diffusive and non-lymphatic convective phosphate transport mechanisms were identifiable. A lymphatic convective phosphate transport mechanism was not identifiable. Furthermore, it was demonstrated that the electrochemical gradient between plasma water and dialysate favours the diffusive phosphate transport, and both electric and chemical potentials must be taken into account in calculations of the transperitoneal phosphate transport.",

keywords = "Adult, Diffusion, Electrophysiology, Female, Humans, Lymphatic System, Male, Models, Biological, Peritoneal Dialysis, Phosphates, Protein Binding",

author = "J Graff and S Fugleberg and J Brahm and N Fogh-Andersen",

year = "1996",

month = may,

language = "English",

volume = "16",

pages = "291--300",

journal = "Clinical Physiology",

issn = "0144-5979",

publisher = "Blackwell Science Ltd.",

number = "3",

}

TY - JOUR

T1 - The transport of phosphate between the plasma and dialysate compartments in peritoneal dialysis is influenced by an electric potential difference

AU - Graff, J

AU - Fugleberg, S

AU - Brahm, J

AU - Fogh-Andersen, N

PY - 1996/5

Y1 - 1996/5

N2 - Six kinetic models of transperitoneal phosphate transport were formulated and validated on the basis of experimental results obtained from 22 non-diabetic patients undergoing peritoneal dialysis. The models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective, and lymphatic convective phosphate transport. Calculations allowed for a 20% protein binding of phosphate. The validation procedure demonstrated that only diffusive and non-lymphatic convective phosphate transport mechanisms were identifiable. A lymphatic convective phosphate transport mechanism was not identifiable. Furthermore, it was demonstrated that the electrochemical gradient between plasma water and dialysate favours the diffusive phosphate transport, and both electric and chemical potentials must be taken into account in calculations of the transperitoneal phosphate transport.

AB - Six kinetic models of transperitoneal phosphate transport were formulated and validated on the basis of experimental results obtained from 22 non-diabetic patients undergoing peritoneal dialysis. The models were designed to elucidate the presence or absence of diffusive, non-lymphatic convective, and lymphatic convective phosphate transport. Calculations allowed for a 20% protein binding of phosphate. The validation procedure demonstrated that only diffusive and non-lymphatic convective phosphate transport mechanisms were identifiable. A lymphatic convective phosphate transport mechanism was not identifiable. Furthermore, it was demonstrated that the electrochemical gradient between plasma water and dialysate favours the diffusive phosphate transport, and both electric and chemical potentials must be taken into account in calculations of the transperitoneal phosphate transport.

KW - Adult

KW - Diffusion

KW - Electrophysiology

KW - Female

KW - Humans

KW - Lymphatic System

KW - Male

KW - Models, Biological

KW - Peritoneal Dialysis

KW - Phosphates

KW - Protein Binding

M3 - Journal article

C2 - 8736715

SN - 0144-5979

VL - 16

SP - 291

EP - 300

JO - Clinical Physiology

JF - Clinical Physiology

IS - 3

ER -

The transport of phosphate between the plasma and dialysate compartments in peritoneal dialysis is influenced by an electric potential difference

Abstract

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