The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe

TY - JOUR

T1 - The sxa2-dependent inactivation of the P-factor mating pheromone in the fission yeast Schizosaccharomyces pombe

AU - Ladds, G

AU - Rasmussen, E M

AU - Young, T

AU - Nielsen, O

AU - Davey, William John

AU - Nielsen, Olaf

PY - 1996/4/1

Y1 - 1996/4/1

N2 - Haploid cells of the fission yeast Schizosaccharomyces pombe exist in one of two mating types, referred to as M and P. Conjugation occurs between cells of opposite mating type and is controlled by the reciprocal action of diffusible pheromones. Loss of function of the sxa2 gene in M cells causes hypersensitivity to the P-factor mating pheromone and a reduction in mating efficiency. Here we demonstrate the secretion of an sxa2-dependent carboxypeptidase that inactivates P-factor by removal of the C-terminal leucine residue.

AB - Haploid cells of the fission yeast Schizosaccharomyces pombe exist in one of two mating types, referred to as M and P. Conjugation occurs between cells of opposite mating type and is controlled by the reciprocal action of diffusible pheromones. Loss of function of the sxa2 gene in M cells causes hypersensitivity to the P-factor mating pheromone and a reduction in mating efficiency. Here we demonstrate the secretion of an sxa2-dependent carboxypeptidase that inactivates P-factor by removal of the C-terminal leucine residue.

KW - Carboxypeptidases

KW - Gene Expression Regulation, Fungal

KW - Genes, Fungal

KW - Genes, Mating Type, Fungal

KW - Hydrogen-Ion Concentration

KW - Pheromones

KW - Schizosaccharomyces

KW - Schizosaccharomyces pombe Proteins

KW - Temperature

KW - Transcription Factors

M3 - Journal article

C2 - 8861202

SN - 0950-382X

VL - 20

SP - 35

EP - 42

JO - Molecular Microbiology

JF - Molecular Microbiology

IS - 1

ER -