The structure and function of endophilin proteins

TY - JOUR

T1 - The structure and function of endophilin proteins

AU - Kjaerulff, Ole

AU - Brodin, Lennart

AU - Jung, Anita

PY - 2011/7/1

Y1 - 2011/7/1

N2 - Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require remodeling of the membrane structure. Here, we discuss the role of endophilins in these processes and summarize novel insights into the molecular aspects of endophilin function. Also, we discuss phosphorylation of endophilins and how this and other mechanisms may contribute to disease.

AB - Members of the BAR domain protein superfamily are essential elements of cellular traffic. Endophilins are among the best studied BAR domain proteins. They have a prominent function in synaptic vesicle endocytosis (SVE), receptor trafficking and apoptosis, and in other processes that require remodeling of the membrane structure. Here, we discuss the role of endophilins in these processes and summarize novel insights into the molecular aspects of endophilin function. Also, we discuss phosphorylation of endophilins and how this and other mechanisms may contribute to disease.

U2 - 10.1007/s12013-010-9137-5

DO - 10.1007/s12013-010-9137-5

M3 - Journal article

C2 - 21184288

SN - 1085-9195

VL - 60

SP - 137

EP - 154

JO - Cell Biochemistry and Biophysics

JF - Cell Biochemistry and Biophysics

IS - 3

ER -