The SH2D2A gene and susceptibility to multiple sclerosis

A.R. Lorentzen; C. Smestad; B.A. Lie; Annette Bang Oturai; E. Akesson; J. Saarela; K.M. Myhr; F. Vartdal; E.G. Celius; Per Soelberg Sørensen; J. Hillert; A. Spurkland; H.F. Harbo

The SH2D2A gene and susceptibility to multiple sclerosis

A.R. Lorentzen, C. Smestad, B.A. Lie, Annette Bang Oturai, E. Akesson, J. Saarela, K.M. Myhr, F. Vartdal, E.G. Celius, Per Soelberg Sørensen, J. Hillert, A. Spurkland, H.F. Harbo

Institut for Klinisk Medicin

13 Citationer (Scopus)

Abstract

We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS
Udgivelsesdato: 2008/7/15

Originalsprog	Engelsk
Tidsskrift	Journal of Neuroimmunology
Vol/bind	197
Udgave nummer	2
Sider (fra-til)	152-158
Antal sider	6
ISSN	0165-5728
Status	Udgivet - 2008

Citationsformater

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title = "The SH2D2A gene and susceptibility to multiple sclerosis",

abstract = "We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS Udgivelsesdato: 2008/7/15",

author = "A.R. Lorentzen and C. Smestad and B.A. Lie and Oturai, {Annette Bang} and E. Akesson and J. Saarela and K.M. Myhr and F. Vartdal and E.G. Celius and S{\o}rensen, {Per Soelberg} and J. Hillert and A. Spurkland and H.F. Harbo",

year = "2008",

language = "English",

volume = "197",

pages = "152--158",

journal = "Journal of Neuroimmunology",

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TY - JOUR

T1 - The SH2D2A gene and susceptibility to multiple sclerosis

AU - Lorentzen, A.R.

AU - Smestad, C.

AU - Lie, B.A.

AU - Oturai, Annette Bang

AU - Akesson, E.

AU - Saarela, J.

AU - Myhr, K.M.

AU - Vartdal, F.

AU - Celius, E.G.

AU - Sørensen, Per Soelberg

AU - Hillert, J.

AU - Spurkland, A.

AU - Harbo, H.F.

PY - 2008

Y1 - 2008

N2 - We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS Udgivelsesdato: 2008/7/15

AB - We previously reported an association between the SH2D2A gene encoding TSAd and multiple sclerosis (MS). Here a total of 2128 Nordic MS patients and 2004 controls were genotyped for the SH2D2A promoter GA repeat polymorphism and rs926103 encoding a serine to asparagine substitution at amino acid position 52 in TSAd. The GA(16)-rs926103()A haplotype was associated with MS in Norwegians (OR 1.4, P=0.04). A similar trend was observed among Danes. In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS Udgivelsesdato: 2008/7/15

M3 - Journal article

SN - 0165-5728

VL - 197

SP - 152

EP - 158

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 2

ER -