The search for neuroimaging and cognitive endophenotypes: A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder

TY - JOUR

T1 - The search for neuroimaging and cognitive endophenotypes

T2 - A critical systematic review of studies involving unaffected first-degree relatives of individuals with bipolar disorder

AU - Miskowiak, Kamilla W.

AU - Kjærstad, Hanne L

AU - Meluken, Iselin

AU - Petersen, Jeff Zarp

AU - Maciel, Beatriz R.

AU - Köhler, Cristiano A

AU - Vinberg, Maj

AU - Kessing, Lars V.

AU - Carvalho, André F

PY - 2017/2

Y1 - 2017/2

N2 - The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: ‘cold’ and ‘hot’ cognition and functional and structural neuroimaging. Seventy-seven cross-sectional studies met the inclusion criteria. The present review revealed that URs in comparison with HCs showed: (i) widespread deficits in verbal memory, sustained attention, and executive function; (ii) abnormalities in the reactivity to and regulation of emotional information along with aberrant reward processing, and heightened attentional interference by emotional stimuli; and (iii) less consistency in the findings regarding structural and resting state neuroimaging, and electrophysiological measures.

AB - The phenomenology and underlying pathophysiology of bipolar disorder (BD) are heterogeneous. The identification of putative endophenotypes for BD can aid in the investigation of unique patho-etiological pathways, which may lead to the development of personalised preventative and therapeutic approaches for this multi-faceted disorder. We included original studies involving unaffected first-degree relatives of BD patients (URs) and a healthy control (HC) comparison group with no first-degree family history of mental disorders, investigating: ‘cold’ and ‘hot’ cognition and functional and structural neuroimaging. Seventy-seven cross-sectional studies met the inclusion criteria. The present review revealed that URs in comparison with HCs showed: (i) widespread deficits in verbal memory, sustained attention, and executive function; (ii) abnormalities in the reactivity to and regulation of emotional information along with aberrant reward processing, and heightened attentional interference by emotional stimuli; and (iii) less consistency in the findings regarding structural and resting state neuroimaging, and electrophysiological measures.

KW - Bipolar disorder

KW - Cognition

KW - Endophenotype

KW - Mood disorder

KW - Neurocognition

KW - Neuroimaging

KW - Pathophysiology

KW - Psychiatry

U2 - 10.1016/j.neubiorev.2016.12.011

DO - 10.1016/j.neubiorev.2016.12.011

M3 - Review

C2 - 27979650

AN - SCOPUS:85006957493

SN - 0149-7634

VL - 73

SP - 1

EP - 22

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -