The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Rachel J Perry; Varman T. Samuel; Kitt Mia Falck Petersen; Gerald I. Shulmann

doi:10.1038/nature13478

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Rachel J Perry, Varman T. Samuel, Kitt Mia Falck Petersen, Gerald I. Shulmann

586 Citationer (Scopus)

Abstract

Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase CÎμ in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

Originalsprog	Engelsk
Tidsskrift	Nature
Vol/bind	510
Sider (fra-til)	84-91
Antal sider	8
ISSN	0028-0836
DOI	https://doi.org/10.1038/nature13478
Status	Udgivet - 5 jun. 2014

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title = "The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes",

abstract = "Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase C{\^I}μ in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.",

author = "Perry, {Rachel J} and Samuel, {Varman T.} and Petersen, {Kitt Mia Falck} and Shulmann, {Gerald I.}",

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AU - Perry, Rachel J

AU - Samuel, Varman T.

AU - Petersen, Kitt Mia Falck

AU - Shulmann, Gerald I.

PY - 2014/6/5

Y1 - 2014/6/5

N2 - Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase CÎμ in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

AB - Non-alcoholic fatty liver disease and its downstream sequelae, hepatic insulin resistance and type 2 diabetes, are rapidly growing epidemics, which lead to increased morbidity and mortality rates, and soaring health-care costs. Developing interventions requires a comprehensive understanding of the mechanisms by which excess hepatic lipid develops and causes hepatic insulin resistance and type 2 diabetes. Proposed mechanisms implicate various lipid species, inflammatory signalling and other cellular modifications. Studies in mice and humans have elucidated a key role for hepatic diacylglycerol activation of protein kinase CÎμ in triggering hepatic insulin resistance. Therapeutic approaches based on this mechanism could alleviate the related epidemics of non-alcoholic fatty liver disease and type 2 diabetes.

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JF - Nature

ER -

The role of hepatic lipids in hepatic insulin resistance and type 2 diabetes

Abstract

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