The role of half-transporters in multidrug resistance

S E Bates; R Robey; K Miyake; K Rao; D D Ross; Thomas Litman

The role of half-transporters in multidrug resistance

S E Bates, R Robey, K Miyake, K Rao, D D Ross, Thomas Litman

Cellebiologi og Fysiologi

124 Citationer (Scopus)

7 Downloads (Pure)

Abstract

ATP-binding cassette proteins comprise a superfamily of transporter proteins, a subset of which have been implicated in multidrug resistance. Although P-glycoprotein was described over 15 years ago, the recent expansion in the number of transporters identified has prompted renewed interest in the role of drug transporters in clinical drug resistance. These newly identified transporters include additional members of the MRP family, ABC2, and a new half-transporter, MXR/BCRP/ABCP1. This half-transporter confers high levels of resistance to mitoxantrone, anthracyclines, and the camptothecins SN-38 and topotecan. At 72 kDa, MXR localizes to the plasma membrane in cells which highly overexpress the protein either through gene amplification or though gene rearrangement. Future studies will be aimed at identifying an inhibitor, and attempting to translate recognition of this new transporter into a target for anticancer treatment.

Originalsprog	Engelsk
Tidsskrift	Journal of Bioenergetics and Biomembranes
Vol/bind	33
Udgave nummer	6
Sider (fra-til)	503-11
Antal sider	9
ISSN	0145-479X
Status	Udgivet - dec. 2001

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The role of half-transporters in multidrug resistanceForlagets udgivne version, 772 KBLicens: Ikke-specificeret

Citationsformater

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abstract = "ATP-binding cassette proteins comprise a superfamily of transporter proteins, a subset of which have been implicated in multidrug resistance. Although P-glycoprotein was described over 15 years ago, the recent expansion in the number of transporters identified has prompted renewed interest in the role of drug transporters in clinical drug resistance. These newly identified transporters include additional members of the MRP family, ABC2, and a new half-transporter, MXR/BCRP/ABCP1. This half-transporter confers high levels of resistance to mitoxantrone, anthracyclines, and the camptothecins SN-38 and topotecan. At 72 kDa, MXR localizes to the plasma membrane in cells which highly overexpress the protein either through gene amplification or though gene rearrangement. Future studies will be aimed at identifying an inhibitor, and attempting to translate recognition of this new transporter into a target for anticancer treatment.",

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T1 - The role of half-transporters in multidrug resistance

AU - Bates, S E

AU - Robey, R

AU - Miyake, K

AU - Rao, K

AU - Ross, D D

AU - Litman, Thomas

PY - 2001/12

Y1 - 2001/12

N2 - ATP-binding cassette proteins comprise a superfamily of transporter proteins, a subset of which have been implicated in multidrug resistance. Although P-glycoprotein was described over 15 years ago, the recent expansion in the number of transporters identified has prompted renewed interest in the role of drug transporters in clinical drug resistance. These newly identified transporters include additional members of the MRP family, ABC2, and a new half-transporter, MXR/BCRP/ABCP1. This half-transporter confers high levels of resistance to mitoxantrone, anthracyclines, and the camptothecins SN-38 and topotecan. At 72 kDa, MXR localizes to the plasma membrane in cells which highly overexpress the protein either through gene amplification or though gene rearrangement. Future studies will be aimed at identifying an inhibitor, and attempting to translate recognition of this new transporter into a target for anticancer treatment.

AB - ATP-binding cassette proteins comprise a superfamily of transporter proteins, a subset of which have been implicated in multidrug resistance. Although P-glycoprotein was described over 15 years ago, the recent expansion in the number of transporters identified has prompted renewed interest in the role of drug transporters in clinical drug resistance. These newly identified transporters include additional members of the MRP family, ABC2, and a new half-transporter, MXR/BCRP/ABCP1. This half-transporter confers high levels of resistance to mitoxantrone, anthracyclines, and the camptothecins SN-38 and topotecan. At 72 kDa, MXR localizes to the plasma membrane in cells which highly overexpress the protein either through gene amplification or though gene rearrangement. Future studies will be aimed at identifying an inhibitor, and attempting to translate recognition of this new transporter into a target for anticancer treatment.

KW - Animals

KW - Drug Resistance, Multiple

KW - Humans

KW - Multidrug Resistance-Associated Proteins

M3 - Journal article

C2 - 11804192

SN - 0145-479X

VL - 33

SP - 503

EP - 511

JO - Journal of Bioenergetics and Biomembranes

JF - Journal of Bioenergetics and Biomembranes

IS - 6

ER -

The role of half-transporters in multidrug resistance

Abstract

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