TY - JOUR
T1 - The role of diabetes on the clinical manifestations of pulmonary tuberculosis
AU - Faurholt-Jepsen, Daniel
AU - Range, Nyagosya
AU - PrayGod, George
AU - Jeremiah, Kidola
AU - Faurholt-Jepsen, Maria
AU - Aabye, Martine G.
AU - Changalucha, John
AU - Christensen, Dirk Lund
AU - Krarup, Henrik Bygum
AU - Witte, Daniel R.
AU - Andersen, Aase B
AU - Friis, Henrik
N1 - IHE 2012 041
PY - 2012/7
Y1 - 2012/7
N2 - Objective Diabetes is associated with pulmonary tuberculosis (TB), possibly due to impaired immunity, and diabetes may exacerbate the clinical manifestations of TB. Our aim was to assess the role of diabetes in the clinical manifestations of TB. Methods We studied 1250 patients with pulmonary TB in an urban population in a cross-sectional study in Tanzania. All participants were tested for diabetes and HIV co-infection, and TB culture intensity was assessed. Levels of white blood cells, haemoglobin, acute phase reactants, CD4 count and HIV viral load were measured, and a qualitative morbidity questionnaire was used to identify the prevalence of disease-related symptoms. Results Tuberculosis patients with diabetes had a higher neutrophil count (B 0.5×109cells/l, 95% CI 0.2; 0.9, P=0.001) than non-diabetic TB patients. Serum C-reactive protein (B 18.8mg/l, CI 95% 8.2; 29.4, P=0.001) and alpha-1-acid glycoprotein (B 0.2g/l, CI 95% 0.03; 0.3, P=0.02) were similarly higher in patients with diabetes. Diabetes did not affect culture intensity or HIV status, but self-reported fever was three times higher among participants with diabetes than in those without diabetes (OR 2.9, CI 95% 1.5; 5.7, P=0.002). Conclusion Diabetes is associated with small changes in the manifestations of TB, but may have little clinical significance.
AB - Objective Diabetes is associated with pulmonary tuberculosis (TB), possibly due to impaired immunity, and diabetes may exacerbate the clinical manifestations of TB. Our aim was to assess the role of diabetes in the clinical manifestations of TB. Methods We studied 1250 patients with pulmonary TB in an urban population in a cross-sectional study in Tanzania. All participants were tested for diabetes and HIV co-infection, and TB culture intensity was assessed. Levels of white blood cells, haemoglobin, acute phase reactants, CD4 count and HIV viral load were measured, and a qualitative morbidity questionnaire was used to identify the prevalence of disease-related symptoms. Results Tuberculosis patients with diabetes had a higher neutrophil count (B 0.5×109cells/l, 95% CI 0.2; 0.9, P=0.001) than non-diabetic TB patients. Serum C-reactive protein (B 18.8mg/l, CI 95% 8.2; 29.4, P=0.001) and alpha-1-acid glycoprotein (B 0.2g/l, CI 95% 0.03; 0.3, P=0.02) were similarly higher in patients with diabetes. Diabetes did not affect culture intensity or HIV status, but self-reported fever was three times higher among participants with diabetes than in those without diabetes (OR 2.9, CI 95% 1.5; 5.7, P=0.002). Conclusion Diabetes is associated with small changes in the manifestations of TB, but may have little clinical significance.
U2 - 10.1111/j.1365-3156.2012.03002.x
DO - 10.1111/j.1365-3156.2012.03002.x
M3 - Journal article
C2 - 22574967
SN - 1360-2276
VL - 17
SP - 877
EP - 883
JO - Tropical Medicine & International Health
JF - Tropical Medicine & International Health
IS - 7
ER -
