The role of dendritic cells in cancer

TY - JOUR

T1 - The role of dendritic cells in cancer

AU - Hansen, Morten

AU - Andersen, Mads Hald

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Though present in low numbers, dendritic cells (DCs) are recognized as major players in the control of cancer by adaptive immunity. The roles of cytotoxic CD8+ T-cells and Th1 helper CD4+ T-cells are well-documented in murine models of cancer and associated with a profound prognostic impact when infiltrating human tumors, but less information is known about how these T-cells gain access to the tumor or how they are primed to become tumor-specific. Here, we highlight recent findings that demonstrate a vital role of CD103+ DCs, which have been shown to be experts in cross-priming and the induction of anti-tumor immunity. We also focus on two different mediators that impair the function of tumor-associated DCs: prostaglandin E2 and β-catenin. Both of these mediators seem to be important for the exclusion of T-cells in the tumor microenvironment and may represent key pathways to target in optimized treatment regimens against cancer.

AB - Though present in low numbers, dendritic cells (DCs) are recognized as major players in the control of cancer by adaptive immunity. The roles of cytotoxic CD8+ T-cells and Th1 helper CD4+ T-cells are well-documented in murine models of cancer and associated with a profound prognostic impact when infiltrating human tumors, but less information is known about how these T-cells gain access to the tumor or how they are primed to become tumor-specific. Here, we highlight recent findings that demonstrate a vital role of CD103+ DCs, which have been shown to be experts in cross-priming and the induction of anti-tumor immunity. We also focus on two different mediators that impair the function of tumor-associated DCs: prostaglandin E2 and β-catenin. Both of these mediators seem to be important for the exclusion of T-cells in the tumor microenvironment and may represent key pathways to target in optimized treatment regimens against cancer.

KW - Cancer

KW - CD103

KW - Dendritic cells

KW - Immunology

KW - PGE

KW - β-catenin

U2 - 10.1007/s00281-016-0592-y

DO - 10.1007/s00281-016-0592-y

M3 - Review

C2 - 27638181

AN - SCOPUS:84988427902

SN - 1863-2297

VL - 39

SP - 307

EP - 316

JO - Seminars in Immunopathology

JF - Seminars in Immunopathology

IS - 3

ER -