The role and advances of immunomodulator therapy for inflammatory bowel disease

TY - JOUR

T1 - The role and advances of immunomodulator therapy for inflammatory bowel disease

AU - Nielsen, Ole Haagen

AU - Coskun, Mehmet

AU - Steenholdt, Casper

AU - Rogler, Gerhard

PY - 2015/2/1

Y1 - 2015/2/1

N2 - Immune modulating drugs such as thiopurines (azathioprine and 6-mercaptopurine) and methotrexate has been a mainstay for treatment of inflammatory bowel disease (IBD) for decades. However, despite widely used in IBD, questions still remain concerning the most rational treatment regimens of these agents. Results from a range of recent studies necessitate increased awareness on how to best use these potent drugs in the clinic. As controversy still remains regarding the most appropriate use of immunomodulators, this review is based on scrutinizing the current literature, with emphasis on randomized controlled trials and Cochrane reviews, focusing on aspects that can lead to optimal and evidence-based thiopurine and methotrexate treatment strategies in IBD.

AB - Immune modulating drugs such as thiopurines (azathioprine and 6-mercaptopurine) and methotrexate has been a mainstay for treatment of inflammatory bowel disease (IBD) for decades. However, despite widely used in IBD, questions still remain concerning the most rational treatment regimens of these agents. Results from a range of recent studies necessitate increased awareness on how to best use these potent drugs in the clinic. As controversy still remains regarding the most appropriate use of immunomodulators, this review is based on scrutinizing the current literature, with emphasis on randomized controlled trials and Cochrane reviews, focusing on aspects that can lead to optimal and evidence-based thiopurine and methotrexate treatment strategies in IBD.

KW - 6-Mercaptopurine

KW - Azathioprine

KW - Humans

KW - Immunologic Factors

KW - Immunomodulation

KW - Inflammatory Bowel Diseases

KW - Methotrexate

KW - Treatment Outcome

U2 - 10.1586/17474124.2014.945914

DO - 10.1586/17474124.2014.945914

M3 - Review

C2 - 25101818

SN - 1747-4124

VL - 9

SP - 177

EP - 189

JO - Expert Review of Gastroenterology & Hepatology

JF - Expert Review of Gastroenterology & Hepatology

IS - 2

ER -