The risk of being depressed is significantly higher in cancer patients than in the general population: Prevalence and severity of depressive symptoms across major cancer types

T J Hartung; E Brähler; H Faller; M Härter; A Hinz; C Johansen; M Keller; U Koch; H Schulz; J Weis; A Mehnert

doi:10.1016/j.ejca.2016.11.017

The risk of being depressed is significantly higher in cancer patients than in the general population: Prevalence and severity of depressive symptoms across major cancer types

T J Hartung, E Brähler, H Faller, M Härter, A Hinz, C Johansen, M Keller, U Koch, H Schulz, J Weis, A Mehnert

Institut for Klinisk Medicin

90 Citationer (Scopus)

Abstract

BACKGROUND: Depression is a common co-morbidity of cancer that has a detrimental effect on quality of life, treatment adherence and potentially survival. We conducted an epidemiological multi-center study including a population-based random comparison sample and estimated the prevalence of depressive symptoms by cancer site, thereby identifying cancer patients with the highest prevalence of depression.

PATIENTS AND METHODS: We included 4020 adult cancer inpatients and outpatients from five distinct regions across Germany in a proportional stratified random sample based on the nationwide cancer incidence and a comparison group consisting of 5018 participants. Both groups reported depressive symptoms by filling in the Patient Health Questionnaire (PHQ-9). In multivariate analyses adjusted for age and sex, we calculated the odds of being depressed.

RESULTS: Out of 5818 eligible patients, 69% participated (51% women, mean age = 58 years). We estimated that one in four cancer patients (24%) is depressed (PHQ-9 ≥ 10). The odds of being depressed among cancer patients were more than five times higher than in the general population (OR, 5.4; 95% CI, 4.6-6.2). Patients with pancreatic (M = 8.0, SD = 5.0), thyroid (M = 7.8, SD = 6.3) and brain tumours (M = 7.6, SD = 4.9) showed the highest prevalence, whereas patients with prostate cancer (M = 4.3, SD = 3.8) and malignant melanoma (M = 5.3, SD = 4.3) had the lowest levels of depressive symptoms.

CONCLUSION: Our results help clinicians identify cancer patients in need of psychosocial support when navigating in the growing survivor population.

Originalsprog	Engelsk
Tidsskrift	European Journal of Cancer
Vol/bind	72
Sider (fra-til)	46-53
ISSN	0959-8049
DOI	https://doi.org/10.1016/j.ejca.2016.11.017
Status	Udgivet - 1 feb. 2017

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10.1016/j.ejca.2016.11.017

Citationsformater

Hartung, T. J., Brähler, E., Faller, H., Härter, M., Hinz, A., Johansen, C., Keller, M., Koch, U., Schulz, H., Weis, J., & Mehnert, A. (2017). The risk of being depressed is significantly higher in cancer patients than in the general population: Prevalence and severity of depressive symptoms across major cancer types. European Journal of Cancer, 72, 46-53. https://doi.org/10.1016/j.ejca.2016.11.017

The risk of being depressed is significantly higher in cancer patients than in the general population : Prevalence and severity of depressive symptoms across major cancer types. / Hartung, T J; Brähler, E; Faller, H et al.

I: European Journal of Cancer, Bind 72, 01.02.2017, s. 46-53.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Hartung, TJ, Brähler, E, Faller, H, Härter, M, Hinz, A, Johansen, C, Keller, M, Koch, U, Schulz, H, Weis, J & Mehnert, A 2017, 'The risk of being depressed is significantly higher in cancer patients than in the general population: Prevalence and severity of depressive symptoms across major cancer types', European Journal of Cancer, bind 72, s. 46-53. https://doi.org/10.1016/j.ejca.2016.11.017

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title = "The risk of being depressed is significantly higher in cancer patients than in the general population: Prevalence and severity of depressive symptoms across major cancer types",

abstract = "BACKGROUND: Depression is a common co-morbidity of cancer that has a detrimental effect on quality of life, treatment adherence and potentially survival. We conducted an epidemiological multi-center study including a population-based random comparison sample and estimated the prevalence of depressive symptoms by cancer site, thereby identifying cancer patients with the highest prevalence of depression.PATIENTS AND METHODS: We included 4020 adult cancer inpatients and outpatients from five distinct regions across Germany in a proportional stratified random sample based on the nationwide cancer incidence and a comparison group consisting of 5018 participants. Both groups reported depressive symptoms by filling in the Patient Health Questionnaire (PHQ-9). In multivariate analyses adjusted for age and sex, we calculated the odds of being depressed.RESULTS: Out of 5818 eligible patients, 69% participated (51% women, mean age = 58 years). We estimated that one in four cancer patients (24%) is depressed (PHQ-9 ≥ 10). The odds of being depressed among cancer patients were more than five times higher than in the general population (OR, 5.4; 95% CI, 4.6-6.2). Patients with pancreatic (M = 8.0, SD = 5.0), thyroid (M = 7.8, SD = 6.3) and brain tumours (M = 7.6, SD = 4.9) showed the highest prevalence, whereas patients with prostate cancer (M = 4.3, SD = 3.8) and malignant melanoma (M = 5.3, SD = 4.3) had the lowest levels of depressive symptoms.CONCLUSION: Our results help clinicians identify cancer patients in need of psychosocial support when navigating in the growing survivor population.",

keywords = "Adolescent, Adult, Aged, Depressive Disorder/epidemiology, Female, Germany/epidemiology, Humans, Male, Middle Aged, Multivariate Analysis, Neoplasms/psychology, Prevalence, Psychiatric Status Rating Scales, Young Adult",

author = "Hartung, {T J} and E Br{\"a}hler and H Faller and M H{\"a}rter and A Hinz and C Johansen and M Keller and U Koch and H Schulz and J Weis and A Mehnert",

year = "2017",

month = feb,

day = "1",

doi = "10.1016/j.ejca.2016.11.017",

language = "English",

volume = "72",

pages = "46--53",

journal = "European Journal of Cancer, Supplement",

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TY - JOUR

T1 - The risk of being depressed is significantly higher in cancer patients than in the general population

T2 - Prevalence and severity of depressive symptoms across major cancer types

AU - Hartung, T J

AU - Brähler, E

AU - Faller, H

AU - Härter, M

AU - Hinz, A

AU - Johansen, C

AU - Keller, M

AU - Koch, U

AU - Schulz, H

AU - Weis, J

AU - Mehnert, A

PY - 2017/2/1

Y1 - 2017/2/1

N2 - BACKGROUND: Depression is a common co-morbidity of cancer that has a detrimental effect on quality of life, treatment adherence and potentially survival. We conducted an epidemiological multi-center study including a population-based random comparison sample and estimated the prevalence of depressive symptoms by cancer site, thereby identifying cancer patients with the highest prevalence of depression.PATIENTS AND METHODS: We included 4020 adult cancer inpatients and outpatients from five distinct regions across Germany in a proportional stratified random sample based on the nationwide cancer incidence and a comparison group consisting of 5018 participants. Both groups reported depressive symptoms by filling in the Patient Health Questionnaire (PHQ-9). In multivariate analyses adjusted for age and sex, we calculated the odds of being depressed.RESULTS: Out of 5818 eligible patients, 69% participated (51% women, mean age = 58 years). We estimated that one in four cancer patients (24%) is depressed (PHQ-9 ≥ 10). The odds of being depressed among cancer patients were more than five times higher than in the general population (OR, 5.4; 95% CI, 4.6-6.2). Patients with pancreatic (M = 8.0, SD = 5.0), thyroid (M = 7.8, SD = 6.3) and brain tumours (M = 7.6, SD = 4.9) showed the highest prevalence, whereas patients with prostate cancer (M = 4.3, SD = 3.8) and malignant melanoma (M = 5.3, SD = 4.3) had the lowest levels of depressive symptoms.CONCLUSION: Our results help clinicians identify cancer patients in need of psychosocial support when navigating in the growing survivor population.

AB - BACKGROUND: Depression is a common co-morbidity of cancer that has a detrimental effect on quality of life, treatment adherence and potentially survival. We conducted an epidemiological multi-center study including a population-based random comparison sample and estimated the prevalence of depressive symptoms by cancer site, thereby identifying cancer patients with the highest prevalence of depression.PATIENTS AND METHODS: We included 4020 adult cancer inpatients and outpatients from five distinct regions across Germany in a proportional stratified random sample based on the nationwide cancer incidence and a comparison group consisting of 5018 participants. Both groups reported depressive symptoms by filling in the Patient Health Questionnaire (PHQ-9). In multivariate analyses adjusted for age and sex, we calculated the odds of being depressed.RESULTS: Out of 5818 eligible patients, 69% participated (51% women, mean age = 58 years). We estimated that one in four cancer patients (24%) is depressed (PHQ-9 ≥ 10). The odds of being depressed among cancer patients were more than five times higher than in the general population (OR, 5.4; 95% CI, 4.6-6.2). Patients with pancreatic (M = 8.0, SD = 5.0), thyroid (M = 7.8, SD = 6.3) and brain tumours (M = 7.6, SD = 4.9) showed the highest prevalence, whereas patients with prostate cancer (M = 4.3, SD = 3.8) and malignant melanoma (M = 5.3, SD = 4.3) had the lowest levels of depressive symptoms.CONCLUSION: Our results help clinicians identify cancer patients in need of psychosocial support when navigating in the growing survivor population.

KW - Adolescent

KW - Adult

KW - Aged

KW - Depressive Disorder/epidemiology

KW - Female

KW - Germany/epidemiology

KW - Humans

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Neoplasms/psychology

KW - Prevalence

KW - Psychiatric Status Rating Scales

KW - Young Adult

U2 - 10.1016/j.ejca.2016.11.017

DO - 10.1016/j.ejca.2016.11.017

M3 - Journal article

C2 - 28024266

SN - 0959-8049

VL - 72

SP - 46

EP - 53

JO - European Journal of Cancer, Supplement

JF - European Journal of Cancer, Supplement

ER -

The risk of being depressed is significantly higher in cancer patients than in the general population: Prevalence and severity of depressive symptoms across major cancer types

Abstract

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