The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys

TY - JOUR

T1 - The relation of germ cells per tubule in testes, serum inhibin B and FSH in cryptorchid boys

AU - Cortes, D

AU - Thorup, Jørgen Mogens

AU - Hogdall, E

AU - Norgaard-Pedersen, B

AU - Petersen, B L

AU - Hogdall, C

PY - 2007/2/1

Y1 - 2007/2/1

N2 - At bilateral orchiopexy bilateral biopsies may be indicated to determine fertility potential. It is currently unknown if the serum inhibin B levels at time of orchiopexy reflect the testicular status of the bilaterally cryptorchid child. The aim of this study was to relate the results of inhibin B and FSH measurements with testicular biopsy parameters in bilateral cryptorchid boys. Included were 25 boys with bilateral cryptorchidism, median 2.5 years (9 months to 5.5 years) at surgery for bilateral cryptorchidism with simultaneous testicular biopsies, and blood sample for inhibin B and FSH. The number of spermatogonia and gonocytes was measured in 100 tubular transverse sections, the S/T and the mean-S/T of the patient was found, and expressed as percent of lowest normal value. Inhibin B and FSH were measured and related to age-specific values. Forty percent (10/25) of the patients had very low mean-S/T (mean-S/T

AB - At bilateral orchiopexy bilateral biopsies may be indicated to determine fertility potential. It is currently unknown if the serum inhibin B levels at time of orchiopexy reflect the testicular status of the bilaterally cryptorchid child. The aim of this study was to relate the results of inhibin B and FSH measurements with testicular biopsy parameters in bilateral cryptorchid boys. Included were 25 boys with bilateral cryptorchidism, median 2.5 years (9 months to 5.5 years) at surgery for bilateral cryptorchidism with simultaneous testicular biopsies, and blood sample for inhibin B and FSH. The number of spermatogonia and gonocytes was measured in 100 tubular transverse sections, the S/T and the mean-S/T of the patient was found, and expressed as percent of lowest normal value. Inhibin B and FSH were measured and related to age-specific values. Forty percent (10/25) of the patients had very low mean-S/T (mean-S/T

KW - Child, Preschool

KW - Cryptorchidism

KW - Follicle Stimulating Hormone

KW - Humans

KW - Infant

KW - Inhibins

KW - Male

KW - Seminiferous Tubules

KW - Sperm Count

KW - Spermatozoa

U2 - 10.1007/s00383-006-1839-9

DO - 10.1007/s00383-006-1839-9

M3 - Journal article

C2 - 17171380

SN - 0179-0358

VL - 23

SP - 163

EP - 169

JO - Pediatric Surgery International

JF - Pediatric Surgery International

IS - 2

ER -