The rationale for targeting the LOX family in cancer

TY - JOUR

T1 - The rationale for targeting the LOX family in cancer

AU - Barker, Holly E

AU - Cox, Thomas R

AU - Erler, Janine T

PY - 2012/8

Y1 - 2012/8

N2 - The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the subject of much effort to understand their roles in cancer. In this Review we discuss the roles of members of this family in the remodelling of the tumour microenvironment and their paradoxical roles in tumorigenesis and metastasis. We also discuss how targeting this family of proteins might lead to a new avenue of cancer therapeutics.

AB - The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of evidence implicating the tumour microenvironment as pivotal in all aspects of tumour initiation and progression. Members of the lysyl oxidase (LOX) family of proteins are secreted by tumours and are the subject of much effort to understand their roles in cancer. In this Review we discuss the roles of members of this family in the remodelling of the tumour microenvironment and their paradoxical roles in tumorigenesis and metastasis. We also discuss how targeting this family of proteins might lead to a new avenue of cancer therapeutics.

U2 - 10.1038/nrc3319

DO - 10.1038/nrc3319

M3 - Journal article

C2 - 22810810

SN - 1474-175X

VL - 12

SP - 540

EP - 552

JO - Nature Reviews. Cancer

JF - Nature Reviews. Cancer

IS - 8

ER -