The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

Anna Karin Louise Åkesson; Marite Cardenas Gomez; Giuliano Elia; Marco P. Monopoli; Kenneth A. Dawson

doi:10.1039/c2ra21866f

The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

Anna Karin Louise Åkesson, Marite Cardenas Gomez, Giuliano Elia, Marco P. Monopoli, Kenneth A. Dawson

Kemisk Institut

43 Citationer (Scopus)

Abstract

Dendrimers are polymers with a strong role in nanomedicine. In the current work we have developed a platform for mapping out the biomolecule corona for polyamidoamine (PAMAM) dendrimers. Complement proteins including C3 and C4b were found for the high generation dendrimers, suggesting high affinities to the dendrimers and most importantly complement activation.

Originalsprog	Engelsk
Tidsskrift	R S C Advances
Vol/bind	2
Udgave nummer	30
Sider (fra-til)	11245-11248
Antal sider	4
ISSN	2046-2069
DOI	https://doi.org/10.1039/c2ra21866f
Status	Udgivet - 28 nov. 2012

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10.1039/c2ra21866f

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T2 - PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

AU - Åkesson, Anna Karin Louise

AU - Cardenas Gomez, Marite

AU - Elia, Giuliano

AU - Monopoli, Marco P.

AU - Dawson, Kenneth A.

PY - 2012/11/28

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N2 - Dendrimers are polymers with a strong role in nanomedicine. In the current work we have developed a platform for mapping out the biomolecule corona for polyamidoamine (PAMAM) dendrimers. Complement proteins including C3 and C4b were found for the high generation dendrimers, suggesting high affinities to the dendrimers and most importantly complement activation.

AB - Dendrimers are polymers with a strong role in nanomedicine. In the current work we have developed a platform for mapping out the biomolecule corona for polyamidoamine (PAMAM) dendrimers. Complement proteins including C3 and C4b were found for the high generation dendrimers, suggesting high affinities to the dendrimers and most importantly complement activation.

U2 - 10.1039/c2ra21866f

DO - 10.1039/c2ra21866f

M3 - Journal article

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JO - RSC Advances

JF - RSC Advances

IS - 30

ER -

The protein corona of dendrimers: PAMAM binds and activates complement proteins in human plasma in a generation dependent manner

Abstract

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