Abstract
Background: This study investigated the impact on all-cause mortality of airflow limitation indicative of chronic obstructive pulmonary disease or restrictive spirometry pattern (RSP) in a stable systolic heart failure population. Hypothesis: Decreased lung function indicates poor survival in heart failure. Methods: Inclusion criteria: NYHA class II-IV and left ventricular ejection fraction (LVEF) < 45%. Prognosis was assessed with multivariate Cox proportional hazards models. Two criteria of obstructive airflow limitation were applied: FEV1/FVC < 0.7 (GOLD), and FEV1/FVC < lower limit of normality (LLN). RSP was defined as FEV1/FVC > 0.7 and FVC<80% or FEV1/FVC > LLN and FVC <LLN. Results: There where 573 patients in the cohort (85% of eligible patients in study period). Median follow-up was 4.7 years and 176 patients died (31%). Age, NYHA class, smoking, body mass index and LVEF were independent prognostic factors (p<0.01). Obstructive airflow limitation increased mortality using both criteria (HRGOLD 2.07 [95% CI 1.45–2.95] p<0.01 and HRLLN 2.00 [1.40–2.84] p<0.01) and was an independent marker when using LLN criteria (HR 1.74 [1.17-2.59] p=0.006). RSP was independently associated with mortality when defined as FVC < LLN (HR 1.54 [1.01–2.35] p=0.04) but not as FVC < 80%. Multivariate hazard ratios for a 10% decrease in predicted value of FEV1 or FVC were 1.42 (p<0.001) and 1.33 (p<0.001) in patients exhibiting airflow obstruction, and 1.36 (p=0.031) and 1.38 (p=0.041) in RSP. Conclusions: Presence of obstructive airflow limitation indicative of COPD or RSP were associated with increased all-cause mortality, however only independently when using the LLN definition.
| Originalsprog | Engelsk |
|---|---|
| Tidsskrift | Clinical Cardiology |
| Vol/bind | 40 |
| Udgave nummer | 11 |
| Sider (fra-til) | 1145-1151 |
| ISSN | 0160-9289 |
| DOI | |
| Status | Udgivet - nov. 2017 |