The POU-er of gene nomenclature

Stephen R Frankenberg; Dale Frank; Richard Harland; Andrew D Johnson; Jennifer Nichols; Hitoshi Niwa; Hans R Schöler; Elly Tanaka; Chris Wylie; Joshua M Brickman

doi:10.1242/dev.108407

The POU-er of gene nomenclature

Stephen R Frankenberg, Dale Frank, Richard Harland, Andrew D Johnson, Jennifer Nichols, Hitoshi Niwa, Hans R Schöler, Elly Tanaka, Chris Wylie, Joshua M Brickman

Stem Cell and developmental Biology - early embryonic lineage specification

24 Citationer (Scopus)

Abstract

The pluripotency factor POU5F1 (OCT4) is well known as a key regulator of stem cell fate. Homologues of POU5F1 exist throughout vertebrates, but the evolutionary and functional relationships between the various family members have been unclear. The level to which function has been conserved within this family provides insight into the evolution of early embryonic potency. Here, we seek to clarify the relationship between POU5F1 homologues in the vertebrate lineage, both phylogenetically and functionally. We resolve the confusion over the identity of the zebrafish gene, which was originally named pou2, then changed to pou5f1 and again, more recently, to pou5f3. We argue that the use of correct nomenclature is crucial when discussing the degree to which the networks regulating early embryonic differentiation are conserved.

Originalsprog	Engelsk
Tidsskrift	Development (Cambridge, England)
Vol/bind	141
Udgave nummer	15
Sider (fra-til)	2921-3
Antal sider	3
ISSN	0950-1991
DOI	https://doi.org/10.1242/dev.108407
Status	Udgivet - aug. 2014

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10.1242/dev.108407

https://dev.biologists.org/content/develop/141/15/2921.full.pdf

Citationsformater

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AU - Frankenberg, Stephen R

AU - Frank, Dale

AU - Harland, Richard

AU - Johnson, Andrew D

AU - Nichols, Jennifer

AU - Niwa, Hitoshi

AU - Schöler, Hans R

AU - Tanaka, Elly

AU - Wylie, Chris

AU - Brickman, Joshua M

PY - 2014/8

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N2 - The pluripotency factor POU5F1 (OCT4) is well known as a key regulator of stem cell fate. Homologues of POU5F1 exist throughout vertebrates, but the evolutionary and functional relationships between the various family members have been unclear. The level to which function has been conserved within this family provides insight into the evolution of early embryonic potency. Here, we seek to clarify the relationship between POU5F1 homologues in the vertebrate lineage, both phylogenetically and functionally. We resolve the confusion over the identity of the zebrafish gene, which was originally named pou2, then changed to pou5f1 and again, more recently, to pou5f3. We argue that the use of correct nomenclature is crucial when discussing the degree to which the networks regulating early embryonic differentiation are conserved.

AB - The pluripotency factor POU5F1 (OCT4) is well known as a key regulator of stem cell fate. Homologues of POU5F1 exist throughout vertebrates, but the evolutionary and functional relationships between the various family members have been unclear. The level to which function has been conserved within this family provides insight into the evolution of early embryonic potency. Here, we seek to clarify the relationship between POU5F1 homologues in the vertebrate lineage, both phylogenetically and functionally. We resolve the confusion over the identity of the zebrafish gene, which was originally named pou2, then changed to pou5f1 and again, more recently, to pou5f3. We argue that the use of correct nomenclature is crucial when discussing the degree to which the networks regulating early embryonic differentiation are conserved.

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DO - 10.1242/dev.108407

M3 - Review

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VL - 141

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EP - 2923

JO - Development (Cambridge, England)

JF - Development (Cambridge, England)

IS - 15

ER -

The POU-er of gene nomenclature

Abstract

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