The potential of microRNAs as biofluid markers of neurodegenerative diseases – a systematic review

Pia B Danborg; Anja H Simonsen; Gunhild Waldemar; Niels H H Heegaard

doi:10.3109/1354750x.2014.904001

The potential of microRNAs as biofluid markers of neurodegenerative diseases – a systematic review

Pia B Danborg, Anja H Simonsen, Gunhild Waldemar, Niels H H Heegaard

Institut for Klinisk Medicin

41 Citationer (Scopus)

Abstract

MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.

Originalsprog	Engelsk
Tidsskrift	Biomarkers
Vol/bind	19
Udgave nummer	4
Sider (fra-til)	259-268
Antal sider	10
ISSN	1354-750X
DOI	https://doi.org/10.3109/1354750x.2014.904001
Status	Udgivet - jun. 2014

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10.3109/1354750x.2014.904001

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abstract = "MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.",

keywords = "Biological Markers, Cognition Disorders, Humans, MicroRNAs, Neurodegenerative Diseases",

author = "Danborg, {Pia B} and Simonsen, {Anja H} and Gunhild Waldemar and Heegaard, {Niels H H}",

year = "2014",

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AU - Simonsen, Anja H

AU - Waldemar, Gunhild

AU - Heegaard, Niels H H

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AB - MicroRNAs (miRNA) are biological molecules transcribed from non-protein coding regions of the genome, participating in regulating cellular processes. MiRNAs in biofluids may possess neurodegenerative disease biomarker potential for screening tests, differential diagnosis and disease progression monitoring. This systematic review clarifies biomarker potential of miRNAs detected in biofluids of neurodegenerative disease patients. Thirty-three and ten miRNAs displayed significant expression between patients with multiple sclerosis and Alzheimer's disease, respectively, compared to healthy controls in minimum two studies. Thirty-eight miRNAs showed biomarker potential by distinguishing significantly between minimum two diseases. Summarized data directs future research towards discovering new biomarkers for neurodegenerative diseases.

KW - Biological Markers

KW - Cognition Disorders

KW - Humans

KW - MicroRNAs

KW - Neurodegenerative Diseases

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ER -

The potential of microRNAs as biofluid markers of neurodegenerative diseases – a systematic review

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