The perivascular phagocyte of the mouse pineal gland: An antigen-presenting cell

Morten Møller; Martin F Rath; David C Klein

doi:10.1080/07420520500521855

The perivascular phagocyte of the mouse pineal gland: An antigen-presenting cell

Morten Møller, Martin F Rath, David C Klein

Institut for Neurovidenskab

17 Citationer (Scopus)

Abstract

The perivascular space of the rat pineal gland is known to contain phagocytic cells that are immunoreactive for leukocyte antigens, and thus they appear to belong to the macrophage/microglial cell line. These cells also contain MHC class II proteins. We investigated this cell type in the pineal gland of mice. Actively phagocytosing cells with a prominent lysosomal system were found in the pericapillary spaces of the mouse pineal gland following intravenous injection of horseradish peroxidase. The cells also exhibited strong acid phosphatase activity. Perivascular cells were immunopositive for MHC class II protein and for CD68, a marker of monocytes/phagocytes. This study verifies that perivascular phagocytes with antigen-presenting properties are present in the mouse pineal gland.

Originalsprog	Engelsk
Tidsskrift	Chronobiology International
Vol/bind	23
Udgave nummer	1-2
Sider (fra-til)	393-401
Antal sider	9
ISSN	0742-0528
DOI	https://doi.org/10.1080/07420520500521855
Status	Udgivet - 1 jan. 2006

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10.1080/07420520500521855

Citationsformater

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title = "The perivascular phagocyte of the mouse pineal gland: An antigen-presenting cell",

abstract = "The perivascular space of the rat pineal gland is known to contain phagocytic cells that are immunoreactive for leukocyte antigens, and thus they appear to belong to the macrophage/microglial cell line. These cells also contain MHC class II proteins. We investigated this cell type in the pineal gland of mice. Actively phagocytosing cells with a prominent lysosomal system were found in the pericapillary spaces of the mouse pineal gland following intravenous injection of horseradish peroxidase. The cells also exhibited strong acid phosphatase activity. Perivascular cells were immunopositive for MHC class II protein and for CD68, a marker of monocytes/phagocytes. This study verifies that perivascular phagocytes with antigen-presenting properties are present in the mouse pineal gland.",

keywords = "Acid Phosphatase, Animals, Antigen-Presenting Cells, Antigens, CD, Antigens, Differentiation, Myelomonocytic, Immunohistochemistry, Mice, Mice, Inbred BALB C, Mice, Inbred C57BL, Microscopy, Electron, Microscopy, Electron, Transmission, Monocytes, Phagocytes, Phagocytosis, Pineal Gland",

author = "Morten M{\o}ller and Rath, {Martin F} and Klein, {David C}",

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T1 - The perivascular phagocyte of the mouse pineal gland: An antigen-presenting cell

AU - Møller, Morten

AU - Rath, Martin F

AU - Klein, David C

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Y1 - 2006/1/1

N2 - The perivascular space of the rat pineal gland is known to contain phagocytic cells that are immunoreactive for leukocyte antigens, and thus they appear to belong to the macrophage/microglial cell line. These cells also contain MHC class II proteins. We investigated this cell type in the pineal gland of mice. Actively phagocytosing cells with a prominent lysosomal system were found in the pericapillary spaces of the mouse pineal gland following intravenous injection of horseradish peroxidase. The cells also exhibited strong acid phosphatase activity. Perivascular cells were immunopositive for MHC class II protein and for CD68, a marker of monocytes/phagocytes. This study verifies that perivascular phagocytes with antigen-presenting properties are present in the mouse pineal gland.

AB - The perivascular space of the rat pineal gland is known to contain phagocytic cells that are immunoreactive for leukocyte antigens, and thus they appear to belong to the macrophage/microglial cell line. These cells also contain MHC class II proteins. We investigated this cell type in the pineal gland of mice. Actively phagocytosing cells with a prominent lysosomal system were found in the pericapillary spaces of the mouse pineal gland following intravenous injection of horseradish peroxidase. The cells also exhibited strong acid phosphatase activity. Perivascular cells were immunopositive for MHC class II protein and for CD68, a marker of monocytes/phagocytes. This study verifies that perivascular phagocytes with antigen-presenting properties are present in the mouse pineal gland.

KW - Acid Phosphatase

KW - Animals

KW - Antigen-Presenting Cells

KW - Antigens, CD

KW - Antigens, Differentiation, Myelomonocytic

KW - Immunohistochemistry

KW - Mice

KW - Mice, Inbred BALB C

KW - Mice, Inbred C57BL

KW - Microscopy, Electron

KW - Microscopy, Electron, Transmission

KW - Monocytes

KW - Phagocytes

KW - Phagocytosis

KW - Pineal Gland

U2 - 10.1080/07420520500521855

DO - 10.1080/07420520500521855

M3 - Journal article

C2 - 16687312

SN - 0742-0528

VL - 23

SP - 393

EP - 401

JO - Chronobiology International

JF - Chronobiology International

IS - 1-2

ER -

The perivascular phagocyte of the mouse pineal gland: An antigen-presenting cell

Abstract

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