TY - JOUR
T1 - The p53 molecule and its prognostic role in squamous cell carcinomas of the head and neck
AU - Nylander, K
AU - Dabelsteen, Erik
AU - Hall, P A
PY - 2000
Y1 - 2000
N2 - Despite intense research, the 5-year survival rate for patients with squamous cell carcinoma of the head and neck (SCCHN) is still low. Several different factors have been studied in the search for one or more factors that give important prognostic information at the time of diagnosis. Many recent studies have focused on the TP53 tumour suppressor gene, analysing its gene status and protein status. When looking at p53 protein expression, using immunohistochemistry, no correlation to patient outcome has been seen for the whole group of SCCHN. However, a significant association between p53 expression and poor patient outcome was found when looking only at patients with laryngeal squamous cell carcinomas. Also, in oral premalignant lesions, expression of p53-positive cells in the suprabasal layers of the epithelium has been seen as an indication of impending malignant development. Concerning the prognostic significance of mutations in the TP53 gene, results differ. But when restricting analysis to tumours with mutations causing an obvious change in protein, TP53 mutation was found to be a strong and independent variable for prognosticating survival. This review article gives an up-to-date overview of the p53 molecule and evaluates its possible prognostic role in SCCHN. Today it is clear that the p53 pathway is very important in SCCHN biology and potentially in its treatment. The function and importance of a few other cell cycle proteins connected to p53 are also discussed.
AB - Despite intense research, the 5-year survival rate for patients with squamous cell carcinoma of the head and neck (SCCHN) is still low. Several different factors have been studied in the search for one or more factors that give important prognostic information at the time of diagnosis. Many recent studies have focused on the TP53 tumour suppressor gene, analysing its gene status and protein status. When looking at p53 protein expression, using immunohistochemistry, no correlation to patient outcome has been seen for the whole group of SCCHN. However, a significant association between p53 expression and poor patient outcome was found when looking only at patients with laryngeal squamous cell carcinomas. Also, in oral premalignant lesions, expression of p53-positive cells in the suprabasal layers of the epithelium has been seen as an indication of impending malignant development. Concerning the prognostic significance of mutations in the TP53 gene, results differ. But when restricting analysis to tumours with mutations causing an obvious change in protein, TP53 mutation was found to be a strong and independent variable for prognosticating survival. This review article gives an up-to-date overview of the p53 molecule and evaluates its possible prognostic role in SCCHN. Today it is clear that the p53 pathway is very important in SCCHN biology and potentially in its treatment. The function and importance of a few other cell cycle proteins connected to p53 are also discussed.
KW - Carcinoma, Squamous Cell
KW - Cyclin-Dependent Kinases
KW - DNA-Binding Proteins
KW - Gene Expression Regulation, Neoplastic
KW - Genes, Tumor Suppressor
KW - Genes, p53
KW - Genetic Therapy
KW - Head and Neck Neoplasms
KW - Humans
KW - Laryngeal Neoplasms
KW - Membrane Proteins
KW - Mouth Neoplasms
KW - Mutation
KW - Nuclear Proteins
KW - Phosphoproteins
KW - Prognosis
KW - Proto-Oncogene Proteins
KW - Proto-Oncogene Proteins c-mdm2
KW - Retinoblastoma Protein
KW - Trans-Activators
KW - Transcription Factors
KW - Tumor Markers, Biological
KW - Tumor Suppressor Protein p53
KW - Tumor Suppressor Proteins
M3 - Journal article
C2 - 11016683
SN - 0904-2512
VL - 29
SP - 413
EP - 425
JO - Journal of Oral Pathology and Medicine
JF - Journal of Oral Pathology and Medicine
IS - 9
ER -