The new Scandinavian Donations and Transfusions database (SCANDAT2): a blood safety resource with added versatility

Gustaf Edgren; Klaus Rostgaard; Senthil K Vasan; Agneta Wikman; Rut Norda; Ole Birger Vesterager Pedersen; Christian Erikstrup; Kaspar René Nielsen; Kjell Titlestad; Henrik Ullum; Mads Melbye; Olof Nyrén; Henrik Hjalgrim

doi:10.1111/trf.12986

The new Scandinavian Donations and Transfusions database (SCANDAT2): a blood safety resource with added versatility

Gustaf Edgren, Klaus Rostgaard, Senthil K Vasan, Agneta Wikman, Rut Norda, Ole Birger Vesterager Pedersen, Christian Erikstrup, Kaspar René Nielsen, Kjell Titlestad, Henrik Ullum, Mads Melbye, Olof Nyrén, Henrik Hjalgrim

Institut for Klinisk Medicin

51 Citationer (Scopus)

Abstract

BACKGROUND: Risks of transfusion-transmitted disease are currently at a record low in the developed world. Still, available methods for blood surveillance might not be sufficient to detect transmission of diseases with unknown etiologies or with very long incubation periods.

STUDY DESIGN AND METHODS: We have previously created the anonymized Scandinavian Donations and Transfusions (SCANDAT) database, containing data on blood donors, blood transfusions, and transfused patients, with complete follow-up of donors and patients for a range of health outcomes. Here we describe the re-creation of SCANDAT with updated, identifiable data. We collected computerized data on blood donations and transfusions from blood banks covering all of Sweden and Denmark. After data cleaning, two structurally identical databases were created and the entire database was linked with nationwide health outcomes registers to attain complete follow-up for up to 47 years regarding hospital care, cancer, and death.

RESULTS: After removal of erroneous records, the database contained 25,523,334 donation records, 21,318,794 transfusion records, and 3,692,653 unique persons with valid identification, presently followed over 40 million person-years, with possibility for future extension. Data quality is generally high with 96% of all transfusions being traceable to their respective donation(s) and a very high (>97%) concordance with official statistics on annual number of blood donations and transfusions.

CONCLUSIONS: It is possible to create a binational, nationwide database with almost 50 years of follow-up of blood donors and transfused patients for a range of health outcomes. We aim to use this database for further studies of donor health, transfusion-associated risks, and transfusion-transmitted disease.

Originalsprog	Engelsk
Tidsskrift	Transfusion
Vol/bind	55
Udgave nummer	7
Sider (fra-til)	1600-6
Antal sider	7
ISSN	0041-1132
DOI	https://doi.org/10.1111/trf.12986
Status	Udgivet - 1 jul. 2015

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10.1111/trf.12986

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title = "The new Scandinavian Donations and Transfusions database (SCANDAT2): a blood safety resource with added versatility",

abstract = "BACKGROUND: Risks of transfusion-transmitted disease are currently at a record low in the developed world. Still, available methods for blood surveillance might not be sufficient to detect transmission of diseases with unknown etiologies or with very long incubation periods.STUDY DESIGN AND METHODS: We have previously created the anonymized Scandinavian Donations and Transfusions (SCANDAT) database, containing data on blood donors, blood transfusions, and transfused patients, with complete follow-up of donors and patients for a range of health outcomes. Here we describe the re-creation of SCANDAT with updated, identifiable data. We collected computerized data on blood donations and transfusions from blood banks covering all of Sweden and Denmark. After data cleaning, two structurally identical databases were created and the entire database was linked with nationwide health outcomes registers to attain complete follow-up for up to 47 years regarding hospital care, cancer, and death.RESULTS: After removal of erroneous records, the database contained 25,523,334 donation records, 21,318,794 transfusion records, and 3,692,653 unique persons with valid identification, presently followed over 40 million person-years, with possibility for future extension. Data quality is generally high with 96% of all transfusions being traceable to their respective donation(s) and a very high (>97%) concordance with official statistics on annual number of blood donations and transfusions.CONCLUSIONS: It is possible to create a binational, nationwide database with almost 50 years of follow-up of blood donors and transfused patients for a range of health outcomes. We aim to use this database for further studies of donor health, transfusion-associated risks, and transfusion-transmitted disease.",

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author = "Gustaf Edgren and Klaus Rostgaard and Vasan, {Senthil K} and Agneta Wikman and Rut Norda and Pedersen, {Ole Birger Vesterager} and Christian Erikstrup and Nielsen, {Kaspar Ren{\'e}} and Kjell Titlestad and Henrik Ullum and Mads Melbye and Olof Nyr{\'e}n and Henrik Hjalgrim",

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month = jul,

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doi = "10.1111/trf.12986",

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journal = "Transfusion",

issn = "0041-1132",

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TY - JOUR

T1 - The new Scandinavian Donations and Transfusions database (SCANDAT2)

T2 - a blood safety resource with added versatility

AU - Edgren, Gustaf

AU - Rostgaard, Klaus

AU - Vasan, Senthil K

AU - Wikman, Agneta

AU - Norda, Rut

AU - Pedersen, Ole Birger Vesterager

AU - Erikstrup, Christian

AU - Nielsen, Kaspar René

AU - Titlestad, Kjell

AU - Ullum, Henrik

AU - Melbye, Mads

AU - Nyrén, Olof

AU - Hjalgrim, Henrik

PY - 2015/7/1

Y1 - 2015/7/1

N2 - BACKGROUND: Risks of transfusion-transmitted disease are currently at a record low in the developed world. Still, available methods for blood surveillance might not be sufficient to detect transmission of diseases with unknown etiologies or with very long incubation periods.STUDY DESIGN AND METHODS: We have previously created the anonymized Scandinavian Donations and Transfusions (SCANDAT) database, containing data on blood donors, blood transfusions, and transfused patients, with complete follow-up of donors and patients for a range of health outcomes. Here we describe the re-creation of SCANDAT with updated, identifiable data. We collected computerized data on blood donations and transfusions from blood banks covering all of Sweden and Denmark. After data cleaning, two structurally identical databases were created and the entire database was linked with nationwide health outcomes registers to attain complete follow-up for up to 47 years regarding hospital care, cancer, and death.RESULTS: After removal of erroneous records, the database contained 25,523,334 donation records, 21,318,794 transfusion records, and 3,692,653 unique persons with valid identification, presently followed over 40 million person-years, with possibility for future extension. Data quality is generally high with 96% of all transfusions being traceable to their respective donation(s) and a very high (>97%) concordance with official statistics on annual number of blood donations and transfusions.CONCLUSIONS: It is possible to create a binational, nationwide database with almost 50 years of follow-up of blood donors and transfused patients for a range of health outcomes. We aim to use this database for further studies of donor health, transfusion-associated risks, and transfusion-transmitted disease.

AB - BACKGROUND: Risks of transfusion-transmitted disease are currently at a record low in the developed world. Still, available methods for blood surveillance might not be sufficient to detect transmission of diseases with unknown etiologies or with very long incubation periods.STUDY DESIGN AND METHODS: We have previously created the anonymized Scandinavian Donations and Transfusions (SCANDAT) database, containing data on blood donors, blood transfusions, and transfused patients, with complete follow-up of donors and patients for a range of health outcomes. Here we describe the re-creation of SCANDAT with updated, identifiable data. We collected computerized data on blood donations and transfusions from blood banks covering all of Sweden and Denmark. After data cleaning, two structurally identical databases were created and the entire database was linked with nationwide health outcomes registers to attain complete follow-up for up to 47 years regarding hospital care, cancer, and death.RESULTS: After removal of erroneous records, the database contained 25,523,334 donation records, 21,318,794 transfusion records, and 3,692,653 unique persons with valid identification, presently followed over 40 million person-years, with possibility for future extension. Data quality is generally high with 96% of all transfusions being traceable to their respective donation(s) and a very high (>97%) concordance with official statistics on annual number of blood donations and transfusions.CONCLUSIONS: It is possible to create a binational, nationwide database with almost 50 years of follow-up of blood donors and transfused patients for a range of health outcomes. We aim to use this database for further studies of donor health, transfusion-associated risks, and transfusion-transmitted disease.

KW - Blood Donors

KW - Blood Transfusion

KW - Databases, Factual

KW - Denmark

KW - Female

KW - Humans

KW - Male

KW - Sweden

U2 - 10.1111/trf.12986

DO - 10.1111/trf.12986

M3 - Journal article

C2 - 25573303

SN - 0041-1132

VL - 55

SP - 1600

EP - 1606

JO - Transfusion

JF - Transfusion

IS - 7

ER -

The new Scandinavian Donations and Transfusions database (SCANDAT2): a blood safety resource with added versatility

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