The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

M M Kady; L Brimer; P Furu; E Lemmich; H M Nielsen; S T Thiilborg; Ole Thastrup; S B Christensen

doi:10.1055/s-2006-961479

The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

M M Kady, L Brimer, P Furu, E Lemmich, H M Nielsen, S T Thiilborg, Ole Thastrup, S B Christensen

LUKKET: Institut for Immunologi og Mikrobiologi

18 Citationer (Scopus)

Abstract

The molluscicidal principles of Ethulia conyzoides were identified as ethuliacoumarin A (1) and isoethuliacoumarin A (2). Ethuliacoumarin A possessed an LC90 between 19 and 23.5 ppm depending on the age of the snail against Biomphalaria glabrata, and between 12 and 15 ppm against Bulinus truncatus. In addition, ethuliacoumarin A was found to be cercaricidal at 25 ppm and ovicidal. Ethuliacoumarin has the structural requirements considered essential for anticoagulant activity. Consequently the anticoagulant dicumarol (4) was tested and found to be molluscicidal in the range from 2.5 to 10 ppm. In contrast, the coumarin anticoagulant warfarin (3) did not show molluscicidal activity.

Originalsprog	Engelsk
Tidsskrift	Planta Medica
Vol/bind	58
Udgave nummer	4
Sider (fra-til)	334-7
Antal sider	4
ISSN	0032-0943
DOI	https://doi.org/10.1055/s-2006-961479
Status	Udgivet - 1992

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10.1055/s-2006-961479

Citationsformater

@article{f038c212dbc64b2e95c49cef70c41731,

title = "The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol",

abstract = "The molluscicidal principles of Ethulia conyzoides were identified as ethuliacoumarin A (1) and isoethuliacoumarin A (2). Ethuliacoumarin A possessed an LC90 between 19 and 23.5 ppm depending on the age of the snail against Biomphalaria glabrata, and between 12 and 15 ppm against Bulinus truncatus. In addition, ethuliacoumarin A was found to be cercaricidal at 25 ppm and ovicidal. Ethuliacoumarin has the structural requirements considered essential for anticoagulant activity. Consequently the anticoagulant dicumarol (4) was tested and found to be molluscicidal in the range from 2.5 to 10 ppm. In contrast, the coumarin anticoagulant warfarin (3) did not show molluscicidal activity.",

keywords = "Animals, Anticoagulants, Biomphalaria, Bulinus, Coumarins, Molluscacides, Plants, Medicinal",

author = "Kady, {M M} and L Brimer and P Furu and E Lemmich and Nielsen, {H M} and Thiilborg, {S T} and Ole Thastrup and Christensen, {S B}",

year = "1992",

doi = "10.1055/s-2006-961479",

language = "English",

volume = "58",

pages = "334--7",

journal = "Planta Medica",

issn = "0032-0943",

publisher = "GeorgThieme Verlag",

number = "4",

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TY - JOUR

T1 - The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

AU - Kady, M M

AU - Brimer, L

AU - Furu, P

AU - Lemmich, E

AU - Nielsen, H M

AU - Thiilborg, S T

AU - Thastrup, Ole

AU - Christensen, S B

PY - 1992

Y1 - 1992

N2 - The molluscicidal principles of Ethulia conyzoides were identified as ethuliacoumarin A (1) and isoethuliacoumarin A (2). Ethuliacoumarin A possessed an LC90 between 19 and 23.5 ppm depending on the age of the snail against Biomphalaria glabrata, and between 12 and 15 ppm against Bulinus truncatus. In addition, ethuliacoumarin A was found to be cercaricidal at 25 ppm and ovicidal. Ethuliacoumarin has the structural requirements considered essential for anticoagulant activity. Consequently the anticoagulant dicumarol (4) was tested and found to be molluscicidal in the range from 2.5 to 10 ppm. In contrast, the coumarin anticoagulant warfarin (3) did not show molluscicidal activity.

AB - The molluscicidal principles of Ethulia conyzoides were identified as ethuliacoumarin A (1) and isoethuliacoumarin A (2). Ethuliacoumarin A possessed an LC90 between 19 and 23.5 ppm depending on the age of the snail against Biomphalaria glabrata, and between 12 and 15 ppm against Bulinus truncatus. In addition, ethuliacoumarin A was found to be cercaricidal at 25 ppm and ovicidal. Ethuliacoumarin has the structural requirements considered essential for anticoagulant activity. Consequently the anticoagulant dicumarol (4) was tested and found to be molluscicidal in the range from 2.5 to 10 ppm. In contrast, the coumarin anticoagulant warfarin (3) did not show molluscicidal activity.

KW - Animals

KW - Anticoagulants

KW - Biomphalaria

KW - Bulinus

KW - Coumarins

KW - Molluscacides

KW - Plants, Medicinal

U2 - 10.1055/s-2006-961479

DO - 10.1055/s-2006-961479

M3 - Journal article

C2 - 1438593

SN - 0032-0943

VL - 58

SP - 334

EP - 337

JO - Planta Medica

JF - Planta Medica

IS - 4

ER -

The molluscicidal activity of coumarins from Ethulia conyzoides and of dicumarol

Abstract

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