The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribbles

TY - JOUR

T1 - The miRNA bantam regulates growth and tumorigenesis by repressing the cell cycle regulator tribbles

AU - Gerlach, Stephan U.

AU - Sander, Moritz

AU - Song, Shilin

AU - Herranz, Héctor

PY - 2019

Y1 - 2019

N2 - One of the fundamental issues in biology is understanding how organ size is controlled. Tissue growth has to be carefully regulated to generate well-functioning organs, and defects in growth control can result in tumor formation. The Hippo signaling pathway is a universal growth regulator and has been implicated in cancer. In Drosophila, the Hippo pathway acts through the miRNA bantam to regulate cell proliferation and apoptosis. Even though the bantam targets regulating apoptosis have been determined, the target genes controlling proliferation have not been identified thus far. In this study, we identify the gene tribbles as a direct bantam target gene. Tribbles limits cell proliferation by suppressing G2/M transition. We show that tribbles regulation by bantam is central in controlling tissue growth and tumorigenesis. We expand our study to other cell cycle regulators and show that deregulated G2/M transition can collaborate with oncogene activation driving tumor formation.

AB - One of the fundamental issues in biology is understanding how organ size is controlled. Tissue growth has to be carefully regulated to generate well-functioning organs, and defects in growth control can result in tumor formation. The Hippo signaling pathway is a universal growth regulator and has been implicated in cancer. In Drosophila, the Hippo pathway acts through the miRNA bantam to regulate cell proliferation and apoptosis. Even though the bantam targets regulating apoptosis have been determined, the target genes controlling proliferation have not been identified thus far. In this study, we identify the gene tribbles as a direct bantam target gene. Tribbles limits cell proliferation by suppressing G2/M transition. We show that tribbles regulation by bantam is central in controlling tissue growth and tumorigenesis. We expand our study to other cell cycle regulators and show that deregulated G2/M transition can collaborate with oncogene activation driving tumor formation.

U2 - 10.26508/lsa.201900381

DO - 10.26508/lsa.201900381

M3 - Journal article

C2 - 31331981

AN - SCOPUS:85071182946

SN - 2575-1077

VL - 2

JO - Life Science Alliance

JF - Life Science Alliance

IS - 4

M1 - e201900381

ER -