The microRNA expression profile differs between erythrodermic mycosis fungoides and Sézary syndrome

Anne Hald Rittig; Lise Maria Lindahl; Claus Johansen; Pamela Celis; Niels Ødum; Lars Iversen; Thomas Litman

doi:10.2340/00015555-3306

The microRNA expression profile differs between erythrodermic mycosis fungoides and Sézary syndrome

Anne Hald Rittig^*, Lise Maria Lindahl, Claus Johansen, Pamela Celis, Niels Ødum, Lars Iversen, Thomas Litman

^*Corresponding author af dette arbejde

3 Citationer (Scopus)

6 Downloads (Pure)

Abstract

It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythrodermic mycosis fungoides and Sézary syndrome. Moreover, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases.

Originalsprog	Engelsk
Tidsskrift	Acta Dermato-Venereologica
Vol/bind	99
Udgave nummer	12
Sider (fra-til)	1148-1153
Antal sider	6
ISSN	0001-5555
DOI	https://doi.org/10.2340/00015555-3306
Status	Udgivet - 2019

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10.2340/00015555-3306Licens: CC BY-NC

The microRNA expression profile differs between erythrodermic mycosis fungoides and Sézary syndromeForlagets udgivne version, 5,55 MBLicens: CC BY-NC

Citationsformater

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abstract = "It is difficult to distinguish erythrodermic mycosis fungoides from S{\'e}zary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with S{\'e}zary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of S{\'e}zary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythrodermic mycosis fungoides and S{\'e}zary syndrome. Moreover, erythrodermic mycosis fungoides showed microRNA features overlapping with S{\'e}zary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with S{\'e}zary syndrome. These findings underscore that erythrodermic mycosis fungoides and S{\'e}zary syndrome are different diseases.",

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AU - Rittig, Anne Hald

AU - Lindahl, Lise Maria

AU - Johansen, Claus

AU - Celis, Pamela

AU - Ødum, Niels

AU - Iversen, Lars

AU - Litman, Thomas

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N2 - It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythrodermic mycosis fungoides and Sézary syndrome. Moreover, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases.

AB - It is difficult to distinguish erythrodermic mycosis fungoides from Sézary syndrome due to their similar clinical and histological features. The main purpose of this study was to investigate whether microRNA expression profiles in lesional skin could discriminate patients with erythrodermic mycosis fungoides from those with Sézary syndrome. A further aim was to assess whether the microRNA expression profiles in erythrodermic mycosis fungoides skin was more comparable to microRNA expression profiles of Sézary syndrome or early-stage mycosis fungoides. RNA was extracted from diagnostic skin biopsies, followed by quantitative reverse transcription polymerase chain reaction analysis of 383 microRNAs. Twenty-seven microRNAs were significantly differentially expressed between erythrodermic mycosis fungoides and Sézary syndrome. Moreover, erythrodermic mycosis fungoides showed microRNA features overlapping with Sézary syndrome and early-stage mycosis fungoides, although hierarchical cluster analysis co-clustered erythrodermic mycosis fungoides with early-stage mycosis fungoides rather than with Sézary syndrome. These findings underscore that erythrodermic mycosis fungoides and Sézary syndrome are different diseases.

KW - Cutaneous T-cell lymphoma

KW - MicroRNA

KW - Mycosis fungoides

KW - Sézary syndrome

U2 - 10.2340/00015555-3306

DO - 10.2340/00015555-3306

M3 - Journal article

C2 - 31453630

AN - SCOPUS:85074366532

SN - 0001-5555

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EP - 1153

JO - Acta Dermato-Venereologica

JF - Acta Dermato-Venereologica

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ER -

The microRNA expression profile differs between erythrodermic mycosis fungoides and Sézary syndrome

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